20993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 271540..272074 Replicon chromosome
Accession NC_005126
Organism Photorhabdus luminescens subsp. laumondii TTO1

Toxin (Protein)


Gene name relE Uniprot ID Q7N9Q9
Locus tag PLU_RS01250 Protein ID WP_011144654.1
Coordinates 271784..272074 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q7N9R0
Locus tag PLU_RS01245 Protein ID WP_011144653.1
Coordinates 271540..271794 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLU_RS01220 (plu0249) 266884..267075 + 192 Protein_243 hypothetical protein -
PLU_RS01225 (plu0250) 267752..268495 + 744 WP_011144649.1 class I SAM-dependent methyltransferase -
PLU_RS01230 (plu0251) 268771..269178 - 408 WP_011144650.1 type II toxin-antitoxin system RelE/ParE family toxin -
PLU_RS01235 (plu0252) 269181..269450 - 270 WP_011144651.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PLU_RS01240 (plu0253) 270366..271133 + 768 WP_011144652.1 Fic family protein -
PLU_RS01245 (plu0254) 271540..271794 + 255 WP_011144653.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PLU_RS01250 (plu0255) 271784..272074 + 291 WP_011144654.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PLU_RS01255 (plu0257) 273063..273323 - 261 WP_011144656.1 hypothetical protein -
PLU_RS01260 (plu0258) 273417..273695 - 279 WP_011144657.1 hypothetical protein -
PLU_RS01265 (plu0259) 274351..276432 - 2082 WP_011144658.1 ATP-dependent DNA helicase RecG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11349.32 Da        Isoelectric Point: 9.9557

>T20993 WP_011144654.1 NC_005126:271784-272074 [Photorhabdus laumondii subsp. laumondii TTO1]
MIFNIDFDERALKEWYKLDQSIRDQFKKKLRKLQNNPYIDSARLHGNLAGCFKIKLRSSGFRLVYQVIEEEIVILVIAVG
KREDAKTYEIACKRIV

Download         Length: 291 bp

>T20993 NC_005126:271784-272074 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGATATTTAATATCGATTTCGACGAACGAGCCCTGAAAGAGTGGTACAAACTGGATCAGAGCATACGCGACCAATTTAA
AAAGAAGCTACGGAAGTTACAGAACAATCCCTATATTGATTCAGCCAGATTACACGGTAATCTGGCTGGCTGCTTTAAAA
TTAAACTCCGTTCTTCAGGCTTTCGTCTGGTTTACCAAGTGATAGAAGAAGAGATCGTAATATTGGTGATCGCTGTTGGT
AAACGGGAAGATGCGAAAACTTATGAAATAGCTTGTAAACGAATTGTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9774.19 Da        Isoelectric Point: 4.8485

>AT20993 WP_011144653.1 NC_005126:271540-271794 [Photorhabdus laumondii subsp. laumondii TTO1]
MSTIQIRVDEELKKSAYQTFEKLNLSPSDALRLFLRYVVENEKLPFTEVSVMVADHDEDADILAVVRDRLKNPARRIRVN
LDDI

Download         Length: 255 bp

>AT20993 NC_005126:271540-271794 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGAGTACTATTCAGATCAGAGTTGATGAAGAACTTAAAAAAAGTGCGTATCAGACATTTGAGAAACTGAACTTATCGCC
ATCTGATGCGCTACGTCTCTTTCTGCGATATGTTGTGGAGAATGAAAAGCTGCCGTTCACTGAAGTTTCCGTTATGGTGG
CAGATCATGATGAAGATGCAGACATCTTAGCAGTGGTACGTGACCGTCTTAAAAATCCCGCTAGACGTATCAGGGTAAAC
CTTGATGATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JHV9

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JHC8

References