209929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2695884..2697105 Replicon chromosome
Accession NZ_CP079758
Organism Pseudomonas aeruginosa strain PA0386

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KYE95_RS12750 Protein ID WP_003114949.1
Coordinates 2695884..2696462 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KYE95_RS12755 Protein ID WP_003088112.1
Coordinates 2696551..2697105 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYE95_RS12735 (KYE95_12705) 2691161..2692438 + 1278 WP_003102743.1 TolC family protein -
KYE95_RS12740 (KYE95_12710) 2692428..2694599 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
KYE95_RS12745 (KYE95_12715) 2694589..2695776 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KYE95_RS12750 (KYE95_12720) 2695884..2696462 - 579 WP_003114949.1 HD domain-containing protein Toxin
KYE95_RS12755 (KYE95_12725) 2696551..2697105 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KYE95_RS12760 (KYE95_12730) 2697263..2699458 - 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KYE95_RS12765 (KYE95_12735) 2699463..2699924 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
KYE95_RS12770 (KYE95_12740) 2700255..2700578 + 324 WP_003102734.1 multidrug efflux SMR transporter -
KYE95_RS12775 (KYE95_12745) 2700591..2700989 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KYE95_RS12780 (KYE95_12750) 2700986..2701537 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T209929 WP_003114949.1 NZ_CP079758:c2696462-2695884 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T209929 NZ_CP104343:c200523-200203 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT209929 WP_003088112.1 NZ_CP079758:c2697105-2696551 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT209929 NZ_CP104343:c200210-199938 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References