Detailed information of TA system TA209928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1763436..1764694
• Replicon: chromosome
• Accession: NZ_CP079758
• Organism: Pseudomonas aeruginosa strain PA0386

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: KYE95_RS08370
• Protein ID: WP_003112528.1
• Coordinates: 1763939..1764694 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KYE95_RS08365
• Protein ID: WP_003086329.1
• Coordinates: 1763436..1763804 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYE95_RS08345 (KYE95_08330)	1759599..1759874	+	276	WP_010793902.1	zinc ribbon domain-containing protein	-
KYE95_RS08350 (KYE95_08335)	1759877..1760353	-	477	WP_003112531.1	hypothetical protein	-
KYE95_RS08355 (KYE95_08340)	1760432..1762021	+	1590	WP_010895535.1	aldehyde dehydrogenase family protein	-
KYE95_RS08360 (KYE95_08345)	1762077..1763363	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
KYE95_RS08365 (KYE95_08350)	1763436..1763804	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KYE95_RS08370 (KYE95_08355)	1763939..1764694	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
KYE95_RS08375 (KYE95_08360)	1765462..1766823	+	1362	WP_010895536.1	DNA recombination protein RmuC	-
KYE95_RS08380 (KYE95_08365)	1766978..1769521	-	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T209928 WP_003112528.1 NZ_CP079758:1763939-1764694 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T209928 NZ_CP104342:c2829992-2829810 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAAGGGTTAGTTACAATCTCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT209928 WP_003086329.1 NZ_CP079758:1763436-1763804 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT209928 NZ_CP104342:c2829717-2829313 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7