Detailed information of TA system TA209921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1111962..1113220
• Replicon: chromosome
• Accession: NZ_CP079757
• Organism: Pseudomonas aeruginosa strain PA0200

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: KXJ64_RS05330
• Protein ID: WP_003112528.1
• Coordinates: 1112465..1113220 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KXJ64_RS05325
• Protein ID: WP_003086329.1
• Coordinates: 1111962..1112330 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ64_RS05305 (KXJ64_05290)	1108125..1108400	+	276	WP_010793902.1	zinc ribbon domain-containing protein	-
KXJ64_RS05310 (KXJ64_05295)	1108403..1108879	-	477	WP_003112531.1	hypothetical protein	-
KXJ64_RS05315 (KXJ64_05300)	1108958..1110547	+	1590	WP_010895535.1	aldehyde dehydrogenase family protein	-
KXJ64_RS05320 (KXJ64_05305)	1110603..1111889	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
KXJ64_RS05325 (KXJ64_05310)	1111962..1112330	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KXJ64_RS05330 (KXJ64_05315)	1112465..1113220	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
KXJ64_RS05335 (KXJ64_05320)	1113988..1115349	+	1362	WP_010895536.1	DNA recombination protein RmuC	-
KXJ64_RS05340 (KXJ64_05325)	1115504..1118047	-	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T209921 WP_003112528.1 NZ_CP079757:1112465-1113220 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T209921 NZ_CP104339:c50712-50410 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT209921 WP_003086329.1 NZ_CP079757:1111962-1112330 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT209921 NZ_CP104339:c50409-50128 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7