209920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 792818..793426 Replicon chromosome
Accession NZ_CP079757
Organism Pseudomonas aeruginosa strain PA0200

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag KXJ64_RS03745 Protein ID WP_003114156.1
Coordinates 793079..793426 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag KXJ64_RS03740 Protein ID WP_003114155.1
Coordinates 792818..793069 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ64_RS03720 (KXJ64_03715) 788465..788821 + 357 WP_003114150.1 DUF2523 family protein -
KXJ64_RS03725 (KXJ64_03720) 788825..790099 + 1275 WP_010895520.1 zonular occludens toxin family protein -
KXJ64_RS03730 (KXJ64_03725) 790329..791621 + 1293 WP_003115206.1 hypothetical protein -
KXJ64_RS03735 (KXJ64_03730) 791621..792604 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
KXJ64_RS03740 (KXJ64_03735) 792818..793069 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KXJ64_RS03745 (KXJ64_03740) 793079..793426 + 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXJ64_RS03755 (KXJ64_03750) 793753..794655 - 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
KXJ64_RS03760 (KXJ64_03755) 795107..795844 - 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
KXJ64_RS03765 (KXJ64_03760) 795924..796967 - 1044 WP_003098363.1 L,D-transpeptidase -
KXJ64_RS03770 (KXJ64_03765) 797103..797795 - 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
KXJ64_RS03775 (KXJ64_03770) 797795..798067 - 273 WP_010895521.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 771291..802530 31239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T209920 WP_003114156.1 NZ_CP079757:793079-793426 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T209920 NZ_CP104339:c50409-50128 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT209920 WP_003114155.1 NZ_CP079757:792818-793069 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT209920 NZ_CP104339:c50712-50410 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References