Detailed information of TA system TA209916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 40958..41493
• Replicon: plasmid pNY1A
• Accession: NZ_CP079753
• Organism: Raoultella ornithinolytica strain NY1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6M4NRI2
• Locus tag: KXJ76_RS26565
• Protein ID: WP_032693963.1
• Coordinates: 41206..41493 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2A2B7
• Locus tag: KXJ76_RS26560
• Protein ID: WP_032752108.1
• Coordinates: 40958..41209 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ76_RS26530 (KXJ76_26530)	36202..36633	-	432	WP_004118968.1	conjugation system SOS inhibitor PsiB	-
KXJ76_RS27365	36677..36805	-	129	Protein_44	hypothetical protein	-
KXJ76_RS26535 (KXJ76_26535)	36924..37154	-	231	WP_047665741.1	hypothetical protein	-
KXJ76_RS26540 (KXJ76_26540)	37218..37889	-	672	WP_032700854.1	plasmid partitioning/stability family protein	-
KXJ76_RS26545 (KXJ76_26545)	37892..38863	-	972	WP_077255421.1	plasmid segregation protein ParM	-
KXJ76_RS26550 (KXJ76_26550)	39082..39525	+	444	WP_040118420.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
KXJ76_RS26555 (KXJ76_26555)	39525..40793	+	1269	WP_032752101.1	Y-family DNA polymerase	-
KXJ76_RS26560 (KXJ76_26560)	40958..41209	+	252	WP_032752108.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KXJ76_RS26565 (KXJ76_26565)	41206..41493	+	288	WP_032693963.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KXJ76_RS26570 (KXJ76_26570)	42586..42858	+	273	Protein_52	DNA polymerase V subunit UmuC	-
KXJ76_RS26575 (KXJ76_26575)	43659..44630	-	972	WP_032752114.1	ParB/RepB/Spo0J family plasmid partition protein	-
KXJ76_RS26580 (KXJ76_26580)	44630..45796	-	1167	WP_032752115.1	plasmid-partitioning protein SopA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..167012	167012

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11133.12 Da
• Isoelectric Point: 10.2246

>T209916 WP_032693963.1 NZ_CP079753:41206-41493 [Raoultella ornithinolytica]
MTYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCDEPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Nucleotide

• Length: 288 bp

>T209916 NZ_CP104336:c291128-290847 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9174.43 Da
• Isoelectric Point: 3.9507

>AT209916 WP_032752108.1 NZ_CP079753:40958-41209 [Raoultella ornithinolytica]
MPNIILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCIPAELYEKMLDALDDQELAKLVSERSNQQLLDVDLD
TYL

Nucleotide

• Length: 252 bp

>AT209916 NZ_CP104336:c291431-291129 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Structures

Toxin

• AlphaFold DB: A0A6M4NRI2