Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4236647..4237266 Replicon chromosome
Accession NZ_CP079752
Organism Raoultella ornithinolytica strain NY1

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag KXJ76_RS20045 Protein ID WP_004858783.1
Coordinates 4237048..4237266 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag KXJ76_RS20040 Protein ID WP_004858785.1
Coordinates 4236647..4237021 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ76_RS20030 (KXJ76_20025) 4231758..4232951 + 1194 WP_004858789.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KXJ76_RS20035 (KXJ76_20030) 4232974..4236120 + 3147 WP_004858787.1 multidrug efflux RND transporter permease subunit AcrB -
KXJ76_RS20040 (KXJ76_20035) 4236647..4237021 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
KXJ76_RS20045 (KXJ76_20040) 4237048..4237266 + 219 WP_004858783.1 HHA domain-containing protein Toxin
KXJ76_RS20050 (KXJ76_20045) 4237418..4237984 + 567 WP_004858781.1 maltose O-acetyltransferase -
KXJ76_RS27320 4237956..4238090 - 135 WP_223306663.1 hypothetical protein -
KXJ76_RS20055 (KXJ76_20050) 4238084..4238554 + 471 WP_004858780.1 YlaC family protein -
KXJ76_RS20060 (KXJ76_20055) 4238529..4239980 - 1452 WP_104896844.1 PLP-dependent aminotransferase family protein -
KXJ76_RS20065 (KXJ76_20060) 4240085..4240783 + 699 Protein_3958 GNAT family protein -
KXJ76_RS20070 (KXJ76_20065) 4240780..4240920 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KXJ76_RS20075 (KXJ76_20070) 4240923..4241183 - 261 WP_004858777.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T209913 WP_004858783.1 NZ_CP079752:4237048-4237266 [Raoultella ornithinolytica]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209913 NZ_CP104335:2516497-2516679 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAAGGGTTAGTTACAATCTCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT209913 WP_004858785.1 NZ_CP079752:4236647-4237021 [Raoultella ornithinolytica]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209913 NZ_CP104335:2516772-2517176 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References