Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2426257..2427170 Replicon chromosome
Accession NZ_CP079752
Organism Raoultella ornithinolytica strain NY1

Toxin (Protein)


Gene name - Uniprot ID A0A808Y4A8
Locus tag KXJ76_RS11355 Protein ID WP_015584188.1
Coordinates 2426257..2426730 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KXJ76_RS11360 Protein ID WP_032716402.1
Coordinates 2426727..2427170 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ76_RS11330 (KXJ76_11325) 2422296..2422904 - 609 WP_219173607.1 glutathione S-transferase family protein -
KXJ76_RS11335 (KXJ76_11330) 2423146..2424051 + 906 WP_032716408.1 transcriptional regulator GcvA -
KXJ76_RS11340 (KXJ76_11335) 2424079..2424984 - 906 WP_004862787.1 LysR family transcriptional regulator -
KXJ76_RS11345 (KXJ76_11340) 2425087..2425404 + 318 WP_004862785.1 nuclear transport factor 2 family protein -
KXJ76_RS11350 (KXJ76_11345) 2425397..2426176 + 780 WP_004862782.1 SDR family oxidoreductase -
KXJ76_RS11355 (KXJ76_11350) 2426257..2426730 - 474 WP_015584188.1 RES domain-containing protein Toxin
KXJ76_RS11360 (KXJ76_11355) 2426727..2427170 - 444 WP_032716402.1 DUF2384 domain-containing protein Antitoxin
KXJ76_RS11365 (KXJ76_11360) 2427360..2427926 - 567 WP_015584190.1 DJ-1/PfpI family protein -
KXJ76_RS11370 (KXJ76_11365) 2428324..2429106 + 783 WP_219173609.1 DUF3750 domain-containing protein -
KXJ76_RS11375 (KXJ76_11370) 2429303..2430526 + 1224 WP_048025269.1 zinc metallochaperone GTPase ZigA -
KXJ76_RS11395 (KXJ76_11390) 2431455..2431985 - 531 WP_219173611.1 acid resistance repetitive basic protein Asr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(95-144)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17524.82 Da        Isoelectric Point: 4.8081

>T209911 WP_015584188.1 NZ_CP079752:c2426730-2426257 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Download         Length: 474 bp

>T209911 NZ_CP104331:161607-161756 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16176.42 Da        Isoelectric Point: 4.9405

>AT209911 WP_032716402.1 NZ_CP079752:c2427170-2426727 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSVLDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT209911 NZ_CP104331:c161562-161503 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808Y4A8

Antitoxin

Source ID Structure

References