Detailed information of TA system TA209901

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 907058..907715
• Replicon: chromosome
• Accession: NZ_CP079752
• Organism: Raoultella ornithinolytica strain NY1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KXJ76_RS04400
• Protein ID: WP_086815890.1
• Coordinates: 907305..907715 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A514ELX1
• Locus tag: KXJ76_RS04395
• Protein ID: WP_004867358.1
• Coordinates: 907058..907324 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ76_RS04370 (KXJ76_04370)	902193..903626	-	1434	WP_086815888.1	6-phospho-beta-glucosidase	-
KXJ76_RS04375 (KXJ76_04375)	903746..904474	-	729	WP_004867368.1	MurR/RpiR family transcriptional regulator	-
KXJ76_RS04380 (KXJ76_04380)	904524..904835	+	312	WP_004867365.1	N(4)-acetylcytidine aminohydrolase	-
KXJ76_RS04385 (KXJ76_04385)	904997..905656	+	660	WP_004867362.1	hemolysin III family protein	-
KXJ76_RS04390 (KXJ76_04390)	905778..906761	-	984	WP_015585783.1	tRNA-modifying protein YgfZ	-
KXJ76_RS04395 (KXJ76_04395)	907058..907324	+	267	WP_004867358.1	FAD assembly factor SdhE	Antitoxin
KXJ76_RS04400 (KXJ76_04400)	907305..907715	+	411	WP_086815890.1	protein YgfX	Toxin
KXJ76_RS04405 (KXJ76_04405)	907723..908244	-	522	WP_004867353.1	flavodoxin FldB	-
KXJ76_RS04410 (KXJ76_04410)	908423..909319	+	897	WP_032718225.1	site-specific tyrosine recombinase XerD	-
KXJ76_RS04415 (KXJ76_04415)	909342..910055	+	714	WP_004867349.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KXJ76_RS04420 (KXJ76_04420)	910061..911794	+	1734	WP_064356671.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16256.18 Da
• Isoelectric Point: 11.3349

>T209901 WP_086815890.1 NZ_CP079752:907305-907715 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDTKEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T209901 NZ_CP104330:c3523731-3523390 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10553.05 Da
• Isoelectric Point: 4.8432

>AT209901 WP_004867358.1 NZ_CP079752:907058-907324 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209901 NZ_CP104330:c3524069-3523752 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A514ELX1