Detailed information of TA system TA020990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4575143..4575791
• Replicon: chromosome
• Accession: NC_005125
• Organism: Gloeobacter violaceus PCC 7421

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GLL_RS22365
• Protein ID: WP_011144326.1
• Coordinates: 4575381..4575791 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q7ND94
• Locus tag: GLL_RS22360
• Protein ID: WP_011144325.1
• Coordinates: 4575143..4575379 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLL_RS22325	4570502..4571272	+	771	WP_164929511.1	hypothetical protein	-
GLL_RS22330	4571466..4572248	+	783	WP_011144320.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
GLL_RS22335	4572223..4573140	+	918	WP_011144321.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
GLL_RS22340	4573179..4573334	+	156	WP_164929512.1	hypothetical protein	-
GLL_RS22345	4573668..4574069	+	402	WP_011144322.1	peptide-methionine (R)-S-oxide reductase MsrB	-
GLL_RS22350	4574103..4574627	+	525	WP_011144323.1	heme-binding protein	-
GLL_RS22355	4574687..4575061	-	375	WP_011144324.1	hypothetical protein	-
GLL_RS22360	4575143..4575379	+	237	WP_011144325.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GLL_RS22365	4575381..4575791	+	411	WP_011144326.1	type II toxin-antitoxin system VapC family toxin	Toxin
GLL_RS22370	4575895..4577055	+	1161	WP_011144327.1	acyltransferase	-
GLL_RS22375	4577126..4577938	-	813	WP_011144328.1	hypothetical protein	-
GLL_RS22380	4577935..4578576	-	642	WP_011144329.1	glutathione S-transferase N-terminal domain-containing protein	-
GLL_RS22385	4578620..4579390	-	771	WP_164929513.1	glucose 1-dehydrogenase	-
GLL_RS22390	4579475..4580560	+	1086	WP_011144331.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4553839..4575791	21952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-126)

Antitoxin

• SpoVT-AbrB domain (10-51)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14564.80 Da
• Isoelectric Point: 6.8699

>T20990 WP_011144326.1 NC_005125:4575381-4575791 [Gloeobacter violaceus PCC 7421]
MDTHRYLLDTNIISNLIRYPGGAVAPHIARVGEDKVCTSIIVAGELRFGAVKKGSTRLSAQLETVLSGLDILPFESPGAQ
HYATLRAAIERTGAPIGSNDMFIAAHALSLGLILVTGNLREFARVPGLSVENWLDL

Nucleotide

• Length: 411 bp

>T20990 NC_005125:4575381-4575791 [Gloeobacter violaceus PCC 7421]
ATGGACACTCACCGCTATCTGCTAGACACCAATATCATTTCCAATTTGATCCGGTATCCAGGTGGCGCAGTAGCTCCCCA
CATCGCCCGAGTTGGGGAAGATAAAGTATGTACCAGCATTATTGTCGCCGGTGAACTGCGCTTCGGCGCGGTCAAGAAAG
GCTCGACACGGCTGTCTGCGCAGCTTGAGACAGTATTGTCGGGGCTCGATATATTGCCCTTCGAGTCTCCCGGCGCTCAA
CACTACGCGACCCTGCGAGCAGCTATCGAAAGGACAGGAGCGCCGATTGGCTCCAATGACATGTTTATCGCCGCCCATGC
GCTGTCCCTCGGATTGATTCTGGTGACCGGCAATCTACGTGAATTCGCCCGCGTACCGGGGCTGAGCGTCGAGAACTGGC
TGGATCTTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9124.49 Da
• Isoelectric Point: 5.7186

>AT20990 WP_011144325.1 NC_005125:4575143-4575379 [Gloeobacter violaceus PCC 7421]
MHAERHVRLFRNGRNQALRIPREFELPGDEAIIRKEGDRLIVEPVRRRSLLAILATLKPLDEEFPDIDDFPPLNDVNL

Nucleotide

• Length: 237 bp

>AT20990 NC_005125:4575143-4575379 [Gloeobacter violaceus PCC 7421]
ATGCATGCAGAACGTCACGTTCGTCTTTTCAGAAATGGGCGCAATCAGGCTCTGCGAATTCCTCGTGAGTTTGAATTGCC
CGGCGACGAAGCCATCATTCGCAAAGAAGGCGACCGGCTGATTGTCGAGCCGGTCAGACGACGCTCCCTGCTGGCTATCC
TTGCAACCTTAAAACCCCTCGATGAGGAATTTCCCGACATCGACGATTTTCCGCCTCTCAACGACGTGAATCTGTGA

Structures

Antitoxin

• AlphaFold DB: Q7ND94