209899

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 5114509..5115130 Replicon chromosome
Accession NZ_CP079751
Organism Aeromonas sanarellii strain NS1

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag KXJ75_RS24355 Protein ID WP_019819701.1
Coordinates 5114825..5115130 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag KXJ75_RS24350 Protein ID WP_001172026.1
Coordinates 5114509..5114844 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ75_RS24320 (KXJ75_24290) 5109921..5111228 - 1308 WP_219143182.1 MotA/TolQ/ExbB proton channel family protein -
KXJ75_RS24325 (KXJ75_24295) 5111225..5111986 - 762 WP_219143183.1 DUF3450 domain-containing protein -
KXJ75_RS24330 (KXJ75_24300) 5112199..5112975 + 777 WP_042079092.1 LuxR family transcriptional regulator -
KXJ75_RS24335 (KXJ75_24305) 5113441..5113812 - 372 WP_023294894.1 hypothetical protein -
KXJ75_RS24340 (KXJ75_24310) 5113809..5114135 - 327 WP_000091614.1 hypothetical protein -
KXJ75_RS24345 (KXJ75_24315) 5114159..5114494 - 336 WP_000741275.1 hypothetical protein -
KXJ75_RS24350 (KXJ75_24320) 5114509..5114844 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
KXJ75_RS24355 (KXJ75_24325) 5114825..5115130 - 306 WP_019819701.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXJ75_RS24360 (KXJ75_24330) 5115683..5116810 + 1128 WP_053288160.1 ISAs1-like element ISKpn9 family transposase -
KXJ75_RS24365 (KXJ75_24335) 5116875..5117597 + 723 WP_219143184.1 TorF family putative porin -
KXJ75_RS24370 (KXJ75_24340) 5118013..5119098 - 1086 WP_011913346.1 IS5-like element ISPst12 family transposase -
KXJ75_RS24375 (KXJ75_24345) 5119195..5119566 - 372 WP_063540372.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5113809..5129564 15755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10981.64 Da        Isoelectric Point: 9.8622

>T209899 WP_019819701.1 NZ_CP079751:c5115130-5114825 [Aeromonas sanarellii]
VRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAVFVLHCFQKKSKSGIATPKADMDII
RARLKVAEVLAQELRNAKTNH

Download         Length: 306 bp

>T209899 NZ_CP104330:2609763-2609870 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT209899 WP_001172026.1 NZ_CP079751:c5114844-5114509 [Aeromonas sanarellii]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT209899 NZ_CP104330:c2609713-2609650 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References