Detailed information of TA system TA209898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2861664..2863228
• Replicon: chromosome
• Accession: NZ_CP079751
• Organism: Aeromonas sanarellii strain NS1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2S4TP05
• Locus tag: KXJ75_RS13580
• Protein ID: WP_005329232.1
• Coordinates: 2861918..2863228 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KXJ75_RS13575
• Protein ID: WP_005329233.1
• Coordinates: 2861664..2861918 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ75_RS13550 (KXJ75_13555)	2857239..2857817	-	579	WP_021140685.1	hypothetical protein	-
KXJ75_RS13555 (KXJ75_13560)	2858149..2858601	-	453	WP_219141989.1	DUF2384 domain-containing protein	-
KXJ75_RS13560 (KXJ75_13565)	2858856..2860163	+	1308	WP_021140687.1	Fic family protein	-
KXJ75_RS13565 (KXJ75_13570)	2860242..2860493	+	252	WP_010674977.1	plasmid stabilization protein	-
KXJ75_RS13570 (KXJ75_13575)	2860914..2861162	-	249	WP_160839436.1	hypothetical protein	-
KXJ75_RS13575 (KXJ75_13580)	2861664..2861918	+	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
KXJ75_RS13580 (KXJ75_13585)	2861918..2863228	+	1311	WP_005329232.1	type II toxin-antitoxin system HipA family toxin	Toxin
KXJ75_RS13590 (KXJ75_13595)	2864276..2866446	+	2171	Protein_2685	catalase/peroxidase HPI	-
KXJ75_RS13595 (KXJ75_13600)	2866672..2867076	-	405	WP_219141991.1	hypothetical protein	-
KXJ75_RS13600 (KXJ75_13605)	2867051..2868040	-	990	WP_219144360.1	IS630 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2803092..2906706	103614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49096.31 Da
• Isoelectric Point: 7.1717

>T209898 WP_005329232.1 NZ_CP079751:2861918-2863228 [Aeromonas sanarellii]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Nucleotide

• Length: 1311 bp

>T209898 NZ_CP104330:2609228-2609335 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT209898 WP_005329233.1 NZ_CP079751:2861664-2861918 [Aeromonas sanarellii]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT209898 NZ_CP104330:c2609181-2609115 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A2S4TP05