Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 1488496..1490210 Replicon chromosome
Accession NZ_CP079751
Organism Aeromonas sanarellii strain NS1

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag KXJ75_RS07200 Protein ID WP_219143813.1
Coordinates 1488496..1489149 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag KXJ75_RS07205 Protein ID WP_219143814.1
Coordinates 1489146..1490210 (+) Length 355 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ75_RS07180 (KXJ75_07180) 1484841..1485575 + 735 WP_219143811.1 restriction endonuclease subunit S -
KXJ75_RS07185 (KXJ75_07185) 1485628..1486578 + 951 WP_182927747.1 IS1595-like element ISAeca5 family transposase -
KXJ75_RS07190 (KXJ75_07190) 1486629..1487069 + 441 WP_219143812.1 restriction endonuclease subunit S -
KXJ75_RS07195 (KXJ75_07195) 1487136..1488086 + 951 WP_182927747.1 IS1595-like element ISAeca5 family transposase -
KXJ75_RS07200 (KXJ75_07200) 1488496..1489149 + 654 WP_219143813.1 DUF4433 domain-containing protein Toxin
KXJ75_RS07205 (KXJ75_07205) 1489146..1490210 + 1065 WP_219143814.1 macro domain-containing protein Antitoxin
KXJ75_RS07210 (KXJ75_07210) 1490285..1493416 + 3132 WP_219143815.1 HsdR family type I site-specific deoxyribonuclease -
KXJ75_RS07215 (KXJ75_07215) 1493416..1494129 + 714 WP_005331303.1 SprT family zinc-dependent metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1479625..1606015 126390
- flank IS/Tn - - 1494332..1495282 950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(18-131)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 25333.93 Da        Isoelectric Point: 7.0171

>T209897 WP_219143813.1 NZ_CP079751:1488496-1489149 [Aeromonas sanarellii]
MAYDYSQSLNPQKALIFRIVHRDNLEWILTHGLWAGNGQQQNPHWVHIGLPELIAKRARHPVPLAPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPRRENDEILILVSSLHRLAELGLPFVFTDSHAYYQWANFYVDLGDLGRIDWPLLQRRDFKRDADDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNSVEQCMYRVGVARPVYVRDGWYFR

Download         Length: 654 bp

>T209897 NZ_CP104330:2608693-2608800 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 355 a.a.        Molecular weight: 39545.67 Da        Isoelectric Point: 6.1445

>AT209897 WP_219143814.1 NZ_CP079751:1489146-1490210 [Aeromonas sanarellii]
MILYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPANMRAYAEACKQGDVVTGKMFITQTGELLGPRWIVNFPTK
QHWRNPAQMAWIQDGLQDLRAWLQAQQVSSIAIPPLGAGNGGLPWPEVKQAIETALGDLDIDILLYEPSSQYQNVAKRGG
VAELTPARALIAELVRRYWFLGMECSLLEIQKLAWFLARVIGRNPLGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQS
DKRIPDSKPFDVIWFNEAKKQELAVYLQTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLIAEEGCAPTLSALREGL
HRWPAGTPWGERKARLFDDRSLQIALTRLQQGLV

Download         Length: 1065 bp

>AT209897 NZ_CP104330:c2608646-2608580 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References