Detailed information of TA system TA209890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3888813..3889627
• Replicon: chromosome
• Accession: NZ_CP079747
• Organism: Escherichia coli strain DL21

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: KXJ73_RS18950
• Protein ID: WP_001054376.1
• Coordinates: 3888813..3889070 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: KXJ73_RS18955
• Protein ID: WP_001309181.1
• Coordinates: 3889082..3889627 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXJ73_RS18930 (3884101)	3884101..3885207	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
KXJ73_RS18935 (3885272)	3885272..3886252	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
KXJ73_RS22225 (3886362)	3886362..3886567	+	206	Protein_3710	HNH endonuclease	-
KXJ73_RS18940 (3886835)	3886835..3888075	-	1241	Protein_3711	helicase YjhR	-
KXJ73_RS22230 (3888191)	3888191..3888322	+	132	WP_001309182.1	hypothetical protein	-
KXJ73_RS18950 (3888813)	3888813..3889070	+	258	WP_001054376.1	YjhX family toxin	Toxin
KXJ73_RS18955 (3889082)	3889082..3889627	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
KXJ73_RS18960 (3889683)	3889683..3890429	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
KXJ73_RS18965 (3890598)	3890598..3890816	+	219	Protein_3716	hypothetical protein	-
KXJ73_RS18970 (3890854)	3890854..3890970	+	117	Protein_3717	VOC family protein	-
KXJ73_RS18975 (3891215)	3891215..3892336	+	1122	WP_000010829.1	M42 family metallopeptidase	-
KXJ73_RS18980 (3892333)	3892333..3892611	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
KXJ73_RS18985 (3892623)	3892623..3893936	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fimE / fimB	3879457..3889627	10170

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T209890 WP_001054376.1 NZ_CP079747:3888813-3889070 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T209890 NZ_CP104330:1790523-1790774 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT209890 WP_001309181.1 NZ_CP079747:3889082-3889627 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT209890 NZ_CP104330:1790771-1791025 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8