Detailed information of TA system TA020989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 4312711..4313250
• Replicon: chromosome
• Accession: NC_005125
• Organism: Gloeobacter violaceus PCC 7421

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GLL_RS21200
• Protein ID: WP_011144102.1
• Coordinates: 4312711..4312959 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q7NDW5
• Locus tag: GLL_RS21205
• Protein ID: WP_011144103.1
• Coordinates: 4313008..4313250 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLL_RS21180	4308133..4309875	+	1743	WP_011144098.1	S-layer homology domain-containing protein	-
GLL_RS21185	4309938..4310558	-	621	WP_011144099.1	hypothetical protein	-
GLL_RS21190	4310591..4311484	+	894	WP_164929770.1	ABC transporter ATP-binding protein	-
GLL_RS21195	4311506..4312648	+	1143	WP_011144101.1	MCE family protein	-
GLL_RS21200	4312711..4312959	-	249	WP_011144102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GLL_RS21205	4313008..4313250	-	243	WP_011144103.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GLL_RS21210	4313511..4314464	+	954	WP_011144105.1	ribonuclease Z	-
GLL_RS21215	4314837..4317092	+	2256	WP_011144106.1	VCBS repeat-containing protein	-
GLL_RS21220	4317286..4318047	+	762	WP_164929453.1	Uma2 family endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (11-74)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9402.62 Da
• Isoelectric Point: 7.3572

>T20989 WP_011144102.1 NC_005125:c4312959-4312711 [Gloeobacter violaceus PCC 7421]
MAATPRPPGGAQRNNYLAKLDASFQLLAQEPQRGRACDELRPGYRKYHVGRHLIFYRESEAGLEIIRVLHERMDIDSHLE
DG

Nucleotide

• Length: 249 bp

>T20989 NC_005125:c4312959-4312711 [Gloeobacter violaceus PCC 7421]
TTGGCCGCTACACCGAGGCCACCTGGGGGCGCGCAACGGAACAACTACCTTGCCAAACTGGATGCATCCTTTCAGCTTCT
GGCGCAGGAGCCGCAACGGGGAAGAGCCTGCGATGAGCTTCGGCCCGGATATCGCAAATACCACGTGGGACGGCACCTGA
TTTTCTACCGTGAATCTGAAGCGGGTTTAGAAATCATCCGAGTTTTGCACGAACGCATGGACATAGATTCCCACCTTGAA
GATGGTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8898.88 Da
• Isoelectric Point: 4.8206

>AT20989 WP_011144103.1 NC_005125:c4313250-4313008 [Gloeobacter violaceus PCC 7421]
MQKNTSVTLGEHFEAFIARQIDSGRYASASEAIRAGLRLLEEHEIKFAALRRALQDGESSGLTDYSLHGLLEELDQEHAV

Nucleotide

• Length: 243 bp

>AT20989 NC_005125:c4313250-4313008 [Gloeobacter violaceus PCC 7421]
ATGCAAAAAAATACGAGCGTCACCCTCGGGGAGCATTTTGAAGCGTTTATCGCCAGGCAGATCGACAGCGGGCGTTATGC
CTCCGCCAGTGAAGCGATCCGCGCCGGACTGCGATTGCTCGAAGAGCATGAGATAAAGTTTGCGGCTCTACGCCGCGCTC
TGCAAGACGGTGAGAGCAGCGGTTTGACCGATTATTCTTTGCACGGTTTGCTCGAAGAGCTTGACCAGGAACACGCTGTC
TGA

Structures

Antitoxin

• AlphaFold DB: Q7NDW5