209874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 900596..901250 Replicon chromosome
Accession NZ_CP079747
Organism Escherichia coli strain DL21

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag KXJ73_RS04380 Protein ID WP_000244783.1
Coordinates 900843..901250 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KXJ73_RS04375 Protein ID WP_000354046.1
Coordinates 900596..900862 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ73_RS04350 (895765) 895765..896508 + 744 WP_000951948.1 SDR family oxidoreductase -
KXJ73_RS04355 (896565) 896565..897998 - 1434 WP_012775976.1 6-phospho-beta-glucosidase BglA -
KXJ73_RS04360 (898043) 898043..898354 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
KXJ73_RS04365 (898518) 898518..899177 + 660 WP_000250274.1 hemolysin III family protein -
KXJ73_RS04370 (899373) 899373..900353 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KXJ73_RS04375 (900596) 900596..900862 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KXJ73_RS04380 (900843) 900843..901250 + 408 WP_000244783.1 protein YgfX Toxin
KXJ73_RS04385 (901290) 901290..901811 - 522 WP_001055874.1 flavodoxin FldB -
KXJ73_RS04390 (901923) 901923..902819 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KXJ73_RS04395 (902844) 902844..903554 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KXJ73_RS04400 (903560) 903560..905293 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T209874 WP_000244783.1 NZ_CP079747:900843-901250 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T209874 NZ_CP104328:3903350-3903691 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT209874 WP_000354046.1 NZ_CP079747:900596-900862 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT209874 NZ_CP104328:c3903355-3903279 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References