Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1259160..1259749 Replicon chromosome
Accession NZ_CP079745
Organism Comamonas aquatica strain B1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KXJ72_RS06020 Protein ID WP_219164277.1
Coordinates 1259453..1259749 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KXJ72_RS06015 Protein ID WP_219164276.1
Coordinates 1259160..1259456 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ72_RS05995 (KXJ72_05995) 1255275..1256492 + 1218 WP_219164727.1 integrase arm-type DNA-binding domain-containing protein -
KXJ72_RS06000 (KXJ72_06000) 1256651..1256857 + 207 WP_219164273.1 AlpA family phage regulatory protein -
KXJ72_RS18480 1256869..1257000 + 132 WP_257469227.1 hypothetical protein -
KXJ72_RS06005 (KXJ72_06005) 1257032..1258093 + 1062 WP_219164274.1 IS110 family transposase -
KXJ72_RS06010 (KXJ72_06010) 1258300..1259079 + 780 WP_257469228.1 KilA-N domain-containing protein -
KXJ72_RS06015 (KXJ72_06015) 1259160..1259456 - 297 WP_219164276.1 putative addiction module antidote protein Antitoxin
KXJ72_RS06020 (KXJ72_06020) 1259453..1259749 - 297 WP_219164277.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXJ72_RS06025 (KXJ72_06025) 1261151..1261152 - 2 WP_257469229.1 IS3 family transposase -
KXJ72_RS06030 (KXJ72_06030) 1261497..1262591 - 1095 Protein_1160 IS21 family transposase -
KXJ72_RS06035 (KXJ72_06035) 1263010..1263636 + 627 WP_219164279.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1245118..1267012 21894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-87)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11031.73 Da        Isoelectric Point: 9.5595

>T209870 WP_219164277.1 NZ_CP079745:c1259749-1259453 [Comamonas aquatica]
MYSVIETESFAAWVDGIRDMPTRIRLRRRVNKAKLGNLGDVKAVGDGVWEMREFFGPGWRLYYVQRGDVLIVMLGGGDKS
SQERDIAAAKAIAKEIDL

Download         Length: 297 bp

>T209870 NZ_CP104328:3399214-3399432 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10772.21 Da        Isoelectric Point: 5.1255

>AT209870 WP_219164276.1 NZ_CP079745:c1259456-1259160 [Comamonas aquatica]
MSTIKTRPFDMANHLSSEEEITEYLRQVLEDNDPAELAGALGDIARARGMTQLARDTGLSRESLYKSLSGERAPSSETLF
KVIHAMGFKLTLAPMAQS

Download         Length: 297 bp

>AT209870 NZ_CP104328:3398814-3399188 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References