Detailed information of TA system TA020987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 3728291..3728802
• Replicon: chromosome
• Accession: NC_005125
• Organism: Gloeobacter violaceus PCC 7421

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q7NFJ7
• Locus tag: GLL_RS18190
• Protein ID: WP_011143517.1
• Coordinates: 3728530..3728802 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q7NFJ8
• Locus tag: GLL_RS18185
• Protein ID: WP_011143516.1
• Coordinates: 3728291..3728533 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLL_RS18155	3723745..3724218	-	474	WP_011143509.1	hypothetical protein	-
GLL_RS18165	3725697..3725981	-	285	WP_011143512.1	DUF86 domain-containing protein	-
GLL_RS18170	3725978..3726286	-	309	WP_011143513.1	nucleotidyltransferase domain-containing protein	-
GLL_RS18175	3726339..3727268	-	930	WP_011143514.1	NAD(+) kinase	-
GLL_RS18180	3727270..3728139	-	870	WP_011143515.1	lipoyl synthase	-
GLL_RS18185	3728291..3728533	+	243	WP_011143516.1	ribbon-helix-helix protein, CopG family	Antitoxin
GLL_RS18190	3728530..3728802	+	273	WP_011143517.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GLL_RS18195	3729160..3729495	-	336	WP_011143518.1	hypothetical protein	-
GLL_RS18200	3729583..3730686	+	1104	WP_011143519.1	glycine cleavage system aminomethyltransferase GcvT	-
GLL_RS18205	3730724..3731113	+	390	WP_011143520.1	glycine cleavage system protein GcvH	-
GLL_RS18210	3731119..3731490	+	372	WP_011143521.1	DUF2511 domain-containing protein	-
GLL_RS18215	3731500..3731802	-	303	WP_011143522.1	hypothetical protein	-
GLL_RS18220	3732383..3733081	+	699	WP_011143523.1	RibD family protein	-
GLL_RS18225	3733072..3733581	+	510	WP_011143524.1	M48 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10105.73 Da
• Isoelectric Point: 9.4325

>T20987 WP_011143517.1 NC_005125:3728530-3728802 [Gloeobacter violaceus PCC 7421]
VKIFWSKQAISDLAAVRDYLEAHYPIGAKIVVARIEGAIERLGVYPAMGRTGRREGTRELVVTQTPFVVVYRPHEGYIEI
LSLLHGAQAW

Nucleotide

• Length: 273 bp

>T20987 NC_005125:3728530-3728802 [Gloeobacter violaceus PCC 7421]
GTGAAAATTTTTTGGTCAAAGCAGGCGATTAGCGACCTTGCTGCTGTGCGCGATTATCTTGAAGCGCACTACCCCATCGG
TGCGAAGATCGTGGTAGCCCGTATCGAGGGGGCGATCGAGCGGCTCGGCGTTTATCCGGCTATGGGGCGCACTGGGCGCC
GGGAAGGCACCCGCGAGCTGGTCGTCACCCAAACTCCATTTGTCGTAGTCTACCGACCCCATGAGGGATACATCGAAATT
TTGTCGCTCCTCCATGGAGCGCAAGCCTGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9409.51 Da
• Isoelectric Point: 4.4230

>AT20987 WP_011143516.1 NC_005125:3728291-3728533 [Gloeobacter violaceus PCC 7421]
MARETITIRLESEKKEALDELARLLDRDRTYLINEAIDRYLEVQHWHLEHIDKAIAQADSGEFATEAEVSEAFERLRELP

Nucleotide

• Length: 243 bp

>AT20987 NC_005125:3728291-3728533 [Gloeobacter violaceus PCC 7421]
ATGGCCCGGGAAACAATTACGATCCGGCTCGAAAGCGAGAAAAAAGAGGCATTGGACGAACTTGCCCGCCTGCTCGATCG
CGATCGGACCTACCTCATCAACGAAGCCATCGACCGGTATCTCGAAGTGCAGCACTGGCACCTGGAGCATATCGACAAAG
CCATTGCCCAAGCGGATAGCGGGGAATTTGCCACAGAAGCGGAAGTAAGCGAAGCATTTGAACGTCTACGCGAACTTCCG
TGA

Structures

Toxin

• AlphaFold DB: Q7NFJ7

Antitoxin

• AlphaFold DB: Q7NFJ8