Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 618035..618537 Replicon chromosome
Accession NZ_CP079745
Organism Comamonas aquatica strain B1

Toxin (Protein)


Gene name yoeB Uniprot ID Q5XQD8
Locus tag KXJ72_RS02920 Protein ID WP_032492620.1
Coordinates 618035..618289 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V0BEH6
Locus tag KXJ72_RS02925 Protein ID WP_032492621.1
Coordinates 618286..618537 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ72_RS02895 (KXJ72_02895) 613225..614157 + 933 WP_219163804.1 hypothetical protein -
KXJ72_RS02900 (KXJ72_02900) 614599..615330 - 732 WP_219163805.1 HNH endonuclease -
KXJ72_RS02905 (KXJ72_02905) 615592..616215 - 624 WP_210570728.1 tyrosine-type recombinase/integrase -
KXJ72_RS02910 (KXJ72_02910) 616468..617478 - 1011 WP_219163806.1 integron integrase -
KXJ72_RS02915 (KXJ72_02915) 617682..617918 + 237 WP_024167031.1 trimethoprim-resistant dihydrofolate reductase DfrB4 -
KXJ72_RS02920 (KXJ72_02920) 618035..618289 - 255 WP_032492620.1 Txe/YoeB family addiction module toxin Toxin
KXJ72_RS02925 (KXJ72_02925) 618286..618537 - 252 WP_032492621.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KXJ72_RS02930 (KXJ72_02930) 618711..618893 + 183 Protein_567 GNAT family N-acetyltransferase -
KXJ72_RS02935 (KXJ72_02935) 618962..619744 - 783 WP_001163403.1 IS21-like element IS1326 family helper ATPase IstB -
KXJ72_RS02940 (KXJ72_02940) 619734..621247 - 1514 Protein_569 IS21-like element IS1326 family transposase -
KXJ72_RS18450 621635..621841 + 207 Protein_570 IS3 family transposase -
KXJ72_RS02945 (KXJ72_02945) 622268..623248 + 981 WP_219163807.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn dfrB4 - 617682..621247 3565
- inside Integron - - 616468..618917 2449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10272.81 Da        Isoelectric Point: 9.3585

>T209869 WP_032492620.1 NZ_CP079745:c618289-618035 [Comamonas aquatica]
MRLIFSDDAWEDYLFWQKQDRRMVDRINKLIKETTREPFSGVGKPEPLKHALAGYWSRRITDEHRMVYKVADDALWIVQL
KYHY

Download         Length: 255 bp

>T209869 NZ_CP104328:2610066-2610173 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9244.40 Da        Isoelectric Point: 4.7769

>AT209869 WP_032492621.1 NZ_CP079745:c618537-618286 [Comamonas aquatica]
MDAITYTHARANLAGTMDRVCNDHEPVIITRNGDQSVVILSLEDFQALEETAYLLRSPANAKRLFKSIEQLEAGRGQARE
LAE

Download         Length: 252 bp

>AT209869 NZ_CP104328:c2610016-2609953 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0BEH9

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0BEH6

References