Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 541747..542426 Replicon chromosome
Accession NZ_CP079743
Organism Acinetobacter baumannii strain 04117201

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag KYX50_RS02760 Protein ID WP_000838146.1
Coordinates 541747..541929 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag KYX50_RS02765 Protein ID WP_000966688.1
Coordinates 542022..542426 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX50_RS02725 (KYX50_02735) 536767..537210 + 444 WP_002016455.1 phage tail terminator-like protein -
KYX50_RS02730 (KYX50_02740) 537212..537430 + 219 WP_001277696.1 hypothetical protein -
KYX50_RS02735 (KYX50_02745) 537539..538060 + 522 WP_000749909.1 SH3 domain-containing protein -
KYX50_RS02740 (KYX50_02750) 538157..538509 + 353 Protein_525 hypothetical protein -
KYX50_RS02745 (KYX50_02755) 538509..539900 + 1392 WP_274413426.1 phage tail protein -
KYX50_RS02750 (KYX50_02760) 539918..540835 + 918 WP_000094253.1 phage tail tube protein -
KYX50_RS02755 (KYX50_02765) 540906..541421 + 516 WP_024616020.1 hypothetical protein -
KYX50_RS02760 (KYX50_02770) 541747..541929 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
KYX50_RS02765 (KYX50_02775) 542022..542426 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KYX50_RS02770 (KYX50_02780) 542525..543205 + 681 WP_000721572.1 hypothetical protein -
KYX50_RS02775 (KYX50_02785) 543207..543470 + 264 WP_001275792.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 505817..561254 55437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T209868 WP_000838146.1 NZ_CP079743:541747-541929 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T209868 NZ_CP104328:2609531-2609638 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT209868 WP_000966688.1 NZ_CP079743:542022-542426 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT209868 NZ_CP104328:c2609484-2609418 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References