Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4235546..4237110 Replicon chromosome
Accession NZ_CP079742
Organism Aeromonas rivuli strain 20-VB00005

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KYK33_RS19535 Protein ID WP_224431579.1
Coordinates 4235800..4237110 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KYK33_RS19530 Protein ID WP_042656123.1
Coordinates 4235546..4235800 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYK33_RS19520 (KYK33_19530) 4231246..4233723 - 2478 WP_224431577.1 DEAD/DEAH box helicase family protein -
KYK33_RS19525 (KYK33_19535) 4234511..4235134 - 624 WP_224431578.1 recombinase family protein -
KYK33_RS19530 (KYK33_19540) 4235546..4235800 + 255 WP_042656123.1 helix-turn-helix domain-containing protein Antitoxin
KYK33_RS19535 (KYK33_19545) 4235800..4237110 + 1311 WP_224431579.1 type II toxin-antitoxin system HipA family toxin Toxin
KYK33_RS19540 (KYK33_19550) 4237805..4238323 + 519 WP_224431580.1 type VI secretion system effector Hcp1 -
KYK33_RS19545 (KYK33_19555) 4238382..4238600 + 219 WP_224431581.1 hypothetical protein -
KYK33_RS19550 (KYK33_19560) 4238817..4240706 + 1890 Protein_3770 type VI secretion system tip protein VgrG -
KYK33_RS19555 (KYK33_19565) 4240835..4241629 + 795 WP_224431582.1 DUF4123 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp / vgrG 4221252..4247511 26259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49131.16 Da        Isoelectric Point: 6.8801

>T209866 WP_224431579.1 NZ_CP079742:4235800-4237110 [Aeromonas rivuli]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHGSWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAVGFERVQMEVILNEMASSL
DEVISAVRQQLPDTFPAQIADSILDGLSTRAQRLTL

Download         Length: 1311 bp

>T209866 NZ_CP104328:c2370477-2370301 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9335.70 Da        Isoelectric Point: 7.9834

>AT209866 WP_042656123.1 NZ_CP079742:4235546-4235800 [Aeromonas rivuli]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPISGW
KEEW

Download         Length: 255 bp

>AT209866 NZ_CP104328:c2370255-2369839 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References