Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1486144..1487737 Replicon chromosome
Accession NZ_CP079742
Organism Aeromonas rivuli strain 20-VB00005

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KYK33_RS07045 Protein ID WP_224432518.1
Coordinates 1486144..1487460 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KYK33_RS07050 Protein ID WP_224432519.1
Coordinates 1487444..1487737 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYK33_RS07010 (KYK33_07000) 1481609..1482223 + 615 WP_224432512.1 cytochrome o ubiquinol oxidase subunit III -
KYK33_RS07015 (KYK33_07005) 1482226..1482558 + 333 WP_224432513.1 cytochrome o ubiquinol oxidase subunit IV -
KYK33_RS07020 (KYK33_07010) 1482564..1483457 + 894 WP_224432967.1 heme o synthase -
KYK33_RS07025 (KYK33_07015) 1483690..1485051 + 1362 WP_224432514.1 MFS transporter -
KYK33_RS07030 (KYK33_07020) 1485114..1485482 + 369 WP_224432515.1 DUF1428 domain-containing protein -
KYK33_RS07035 (KYK33_07025) 1485587..1485724 - 138 WP_224432516.1 hypothetical protein -
KYK33_RS07040 (KYK33_07030) 1485803..1486045 - 243 WP_224432517.1 DUF3297 family protein -
KYK33_RS07045 (KYK33_07035) 1486144..1487460 - 1317 WP_224432518.1 HipA domain-containing protein Toxin
KYK33_RS07050 (KYK33_07040) 1487444..1487737 - 294 WP_224432519.1 helix-turn-helix domain-containing protein Antitoxin
KYK33_RS07055 (KYK33_07045) 1488228..1488650 - 423 WP_224432520.1 NUDIX domain-containing protein -
KYK33_RS07060 (KYK33_07050) 1488751..1489173 - 423 WP_224432521.1 VOC family protein -
KYK33_RS07065 (KYK33_07055) 1489288..1490154 - 867 WP_224432522.1 toll/interleukin-1 receptor domain-containing protein -
KYK33_RS07070 (KYK33_07060) 1491242..1492048 - 807 WP_224432523.1 tryptophan synthase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1478613..1490154 11541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-72)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49357.49 Da        Isoelectric Point: 6.4627

>T209865 WP_224432518.1 NZ_CP079742:c1487460-1486144 [Aeromonas rivuli]
MMNGTERHRLELRLGNQLIGHLEYDSSRDAFQLGYTAEWQARGFPLSPPLALDGSASSAQVRAYLGNLLPENRGLEHLIE
ALCVSRSNLFALIHSIGRDVSGAVTFTLPAEQGVPTHFRPITPEELLLRLDQPEIWPLEVWDGRPRLSVAGVQAKLNLLR
LEGTLGFGEGELCSTHLLKFEHHPHLVINEFVTMRLAALLGMQVAQVELHRVGQGDKSHRGLLVERFDRRLDEDGVRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLLSLSALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSRAGLTPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAVNPWQLLEMAEACELPKRLLQQTLHKVANDILHHLDAAIAM
VETDNPAELAYLARYRDDVERRCHHFQAQAALLPELQL

Download         Length: 1317 bp

>T209865 NZ_CP104328:2287587-2288909 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10489.04 Da        Isoelectric Point: 6.2984

>AT209865 WP_224432519.1 NZ_CP079742:c1487737-1487444 [Aeromonas rivuli]
MADASLQTGPKELDPASLGLAIRERRKAARMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQETGS
QVANGNSQPEVGDDEWY

Download         Length: 294 bp

>AT209865 NZ_CP104328:2287321-2287587 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References