Detailed information of TA system TA209861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3908820..3909634
• Replicon: chromosome
• Accession: NZ_CP079736
• Organism: Escherichia coli strain GB2005-delet-a-f

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: KYX13_RS19125
• Protein ID: WP_001054376.1
• Coordinates: 3908820..3909077 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: KYX13_RS19130
• Protein ID: WP_001309181.1
• Coordinates: 3909089..3909634 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYX13_RS19105 (3904108)	3904108..3905214	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
KYX13_RS19110 (3905279)	3905279..3906259	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
KYX13_RS22300 (3906369)	3906369..3906574	+	206	Protein_3745	HNH endonuclease	-
KYX13_RS19115 (3906842)	3906842..3908082	-	1241	Protein_3746	helicase YjhR	-
KYX13_RS22305 (3908198)	3908198..3908329	+	132	WP_001309182.1	hypothetical protein	-
KYX13_RS19125 (3908820)	3908820..3909077	+	258	WP_001054376.1	YjhX family toxin	Toxin
KYX13_RS19130 (3909089)	3909089..3909634	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
KYX13_RS19135 (3909690)	3909690..3910436	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
KYX13_RS19140 (3910605)	3910605..3910823	+	219	Protein_3751	hypothetical protein	-
KYX13_RS19145 (3910861)	3910861..3910977	+	117	Protein_3752	VOC family protein	-
KYX13_RS19150 (3911222)	3911222..3912343	+	1122	WP_000010829.1	M42 family metallopeptidase	-
KYX13_RS19155 (3912340)	3912340..3912618	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
KYX13_RS19160 (3912630)	3912630..3913943	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3894017..3917858	23841

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T209861 WP_001054376.1 NZ_CP079736:3908820-3909077 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T209861 NZ_CP104328:1791074-1791328 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT209861 WP_001309181.1 NZ_CP079736:3909089-3909634 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT209861 NZ_CP104328:1790826-1791077 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8