Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3617901..3618580 | Replicon | chromosome |
| Accession | NZ_CP079736 | ||
| Organism | Escherichia coli strain GB2005-delet-a-f | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | P77692 |
| Locus tag | KYX13_RS17710 | Protein ID | WP_000854672.1 |
| Coordinates | 3618239..3618580 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | Q47684 |
| Locus tag | KYX13_RS17705 | Protein ID | WP_000070395.1 |
| Coordinates | 3617901..3618218 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYX13_RS17655 (3612948) | 3612948..3613811 | + | 864 | WP_001065553.1 | GTPase family protein | - |
| KYX13_RS17660 (3613903) | 3613903..3614724 | + | 822 | WP_000197389.1 | DUF932 domain-containing protein | - |
| KYX13_RS17665 (3614941) | 3614941..3615132 | + | 192 | Protein_3466 | DeoR family transcriptional regulator | - |
| KYX13_RS17670 (3615179) | 3615179..3615355 | + | 177 | WP_001285112.1 | hypothetical protein | - |
| KYX13_RS17675 (3615355) | 3615355..3615798 | + | 444 | WP_000824223.1 | lipoprotein YafY | - |
| KYX13_RS17680 (3615821) | 3615821..3616288 | + | 468 | WP_001547765.1 | protein YkfB | - |
| KYX13_RS17685 (3616365) | 3616365..3616604 | + | 240 | WP_000194654.1 | DUF905 family protein | - |
| KYX13_RS17690 (3616702) | 3616702..3617160 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| KYX13_RS17695 (3617176) | 3617176..3617652 | + | 477 | WP_000811693.1 | RadC family protein | - |
| KYX13_RS17700 (3617661) | 3617661..3617882 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| KYX13_RS17705 (3617901) | 3617901..3618218 | + | 318 | WP_000070395.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| KYX13_RS17710 (3618239) | 3618239..3618580 | + | 342 | WP_000854672.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| KYX13_RS17720 (3619152) | 3619152..3620405 | - | 1254 | WP_000893278.1 | glutamate-5-semialdehyde dehydrogenase | - |
| KYX13_RS17725 (3620417) | 3620417..3621520 | - | 1104 | WP_001285288.1 | glutamate 5-kinase | - |
| KYX13_RS17730 (3621808) | 3621808..3622863 | + | 1056 | WP_000749863.1 | phosphoporin PhoE | - |
| KYX13_RS17735 (3622902) | 3622902..3623303 | - | 402 | WP_000174689.1 | sigma factor-binding protein Crl | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12905.01 Da Isoelectric Point: 9.6543
>T209858 WP_000854672.1 NZ_CP079736:3618239-3618580 [Escherichia coli]
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T209858 NZ_CP104328:c1108618-1108289 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11939.59 Da Isoelectric Point: 6.7391
>AT209858 WP_000070395.1 NZ_CP079736:3617901-3618218 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT209858 NZ_CP104328:c1108956-1108639 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|