Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2236632..2237158 | Replicon | chromosome |
| Accession | NZ_CP079736 | ||
| Organism | Escherichia coli strain GB2005-delet-a-f | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KYX13_RS10835 | Protein ID | WP_000323025.1 |
| Coordinates | 2236871..2237158 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KYX13_RS10830 | Protein ID | WP_000534858.1 |
| Coordinates | 2236632..2236871 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KYX13_RS10775 (2231659) | 2231659..2232426 | - | 768 | Protein_2107 | exonuclease | - |
| KYX13_RS10780 (2232519) | 2232519..2232710 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| KYX13_RS10785 (2232707) | 2232707..2232895 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| KYX13_RS10790 (2233463) | 2233463..2233681 | - | 219 | WP_001171942.1 | protein YdfC | - |
| KYX13_RS22250 (2233711) | 2233711..2233839 | - | 129 | WP_000344964.1 | protein YdfB | - |
| KYX13_RS10795 (2233841) | 2233841..2233996 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| KYX13_RS10800 (2234163) | 2234163..2234570 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| KYX13_RS10805 (2234654) | 2234654..2234884 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| KYX13_RS10810 (2234868) | 2234868..2235146 | + | 279 | Protein_2115 | hypothetical protein | - |
| KYX13_RS10815 (2235181) | 2235181..2235330 | + | 150 | WP_011443592.1 | protein YdfW | - |
| KYX13_RS10820 (2235767) | 2235767..2236099 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KYX13_RS10825 (2236302) | 2236302..2236607 | - | 306 | WP_001326990.1 | protein YdfV | - |
| KYX13_RS10830 (2236632) | 2236632..2236871 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KYX13_RS10835 (2236871) | 2236871..2237158 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KYX13_RS10840 (2237230) | 2237230..2237385 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KYX13_RS10845 (2237602) | 2237602..2237853 | + | 252 | WP_000980994.1 | protein Rem | - |
| KYX13_RS10850 (2237920) | 2237920..2238198 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| KYX13_RS10855 (2238200) | 2238200..2239249 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| KYX13_RS10860 (2239263) | 2239263..2240015 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KYX13_RS10865 (2240293) | 2240293..2240382 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| KYX13_RS10870 (2240437) | 2240437..2240649 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KYX13_RS10875 (2240950) | 2240950..2241165 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KYX13_RS10880 (2241529) | 2241529..2241699 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| KYX13_RS10885 (2241919) | 2241919..2242134 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2228460..2262514 | 34054 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T209854 WP_000323025.1 NZ_CP079736:2236871-2237158 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T209854 NZ_CP104328:651617-651931 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT209854 WP_000534858.1 NZ_CP079736:2236632-2236871 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT209854 NZ_CP104328:651928-652344 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|