Detailed information of TA system TA209834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3907728..3908542
• Replicon: chromosome
• Accession: NZ_CP079735
• Organism: Escherichia coli strain GB2005

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: KYX12_RS19090
• Protein ID: WP_001054376.1
• Coordinates: 3907728..3907985 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: KYX12_RS19095
• Protein ID: WP_001309181.1
• Coordinates: 3907997..3908542 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYX12_RS19070 (3903016)	3903016..3904122	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
KYX12_RS19075 (3904187)	3904187..3905167	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
KYX12_RS22250 (3905277)	3905277..3905482	+	206	Protein_3739	HNH endonuclease	-
KYX12_RS19080 (3905750)	3905750..3906990	-	1241	Protein_3740	helicase YjhR	-
KYX12_RS22255 (3907106)	3907106..3907237	+	132	WP_001309182.1	hypothetical protein	-
KYX12_RS19090 (3907728)	3907728..3907985	+	258	WP_001054376.1	YjhX family toxin	Toxin
KYX12_RS19095 (3907997)	3907997..3908542	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
KYX12_RS19100 (3908598)	3908598..3909344	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
KYX12_RS19105 (3909513)	3909513..3909731	+	219	Protein_3745	hypothetical protein	-
KYX12_RS19110 (3909769)	3909769..3909885	+	117	Protein_3746	VOC family protein	-
KYX12_RS19115 (3910130)	3910130..3911251	+	1122	WP_000010829.1	M42 family metallopeptidase	-
KYX12_RS19120 (3911248)	3911248..3911526	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
KYX12_RS19125 (3911538)	3911538..3912851	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3892925..3916766	23841

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T209834 WP_001054376.1 NZ_CP079735:3907728-3907985 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T209834 NZ_CP104326:2239937-2240224 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT209834 WP_001309181.1 NZ_CP079735:3907997-3908542 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT209834 NZ_CP104326:2239698-2239937 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8