Detailed information of TA system TA020982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1943106..1943647
• Replicon: chromosome
• Accession: NC_005125
• Organism: Gloeobacter violaceus PCC 7421

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q7NJK8
• Locus tag: GLL_RS09455
• Protein ID: WP_011141822.1
• Coordinates: 1943106..1943381 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q7NJK7
• Locus tag: GLL_RS09460
• Protein ID: WP_011141823.1
• Coordinates: 1943372..1943647 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLL_RS09425	1938556..1939116	+	561	WP_011141816.1	sugar O-acetyltransferase	-
GLL_RS09430	1939127..1939813	-	687	WP_164928865.1	peptide-methionine (S)-S-oxide reductase MsrA	-
GLL_RS09435	1940143..1940574	+	432	WP_011141818.1	hypothetical protein	-
GLL_RS09440	1940666..1941328	-	663	WP_011141819.1	endonuclease III	-
GLL_RS09445	1941452..1941919	+	468	WP_011141820.1	MarR family transcriptional regulator	-
GLL_RS09450	1942001..1942699	+	699	WP_011141821.1	pirin family protein	-
GLL_RS09455	1943106..1943381	-	276	WP_011141822.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GLL_RS09460	1943372..1943647	-	276	WP_011141823.1	ribbon-helix-helix domain-containing protein	Antitoxin
GLL_RS09465	1943940..1944875	-	936	WP_197530153.1	helix-turn-helix domain-containing protein	-
GLL_RS09470	1945127..1947022	+	1896	WP_164928866.1	hypothetical protein	-
GLL_RS09475	1947025..1947708	+	684	WP_011141826.1	OmpA family protein	-
GLL_RS09480	1947756..1948415	-	660	WP_011141827.1	translation elongation factor Ts	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-46)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10591.25 Da
• Isoelectric Point: 10.2919

>T20982 WP_011141822.1 NC_005125:c1943381-1943106 [Gloeobacter violaceus PCC 7421]
MQVTWTSKSLEDLARLHAFLRPVNSQAAAAVVRNLTAGAKRLERFPQLGTALPEFAPRDVRRLIIVDYEMRYELKDDAVF
ILRLWHAREDR

Nucleotide

• Length: 276 bp

>T20982 NC_005125:c1943381-1943106 [Gloeobacter violaceus PCC 7421]
ATGCAGGTAACGTGGACAAGCAAGTCCCTTGAGGACTTGGCACGACTTCATGCCTTTCTGAGACCGGTTAATTCACAAGC
CGCCGCCGCTGTGGTCAGAAACCTGACCGCAGGGGCCAAGCGGCTTGAACGATTTCCGCAACTCGGTACAGCTTTGCCGG
AATTTGCCCCGCGTGATGTCCGACGACTGATCATTGTGGACTATGAAATGCGCTATGAGTTGAAGGACGATGCTGTATTT
ATCTTGCGTTTATGGCATGCCCGCGAAGATCGGTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10104.57 Da
• Isoelectric Point: 4.7868

>AT20982 WP_011141823.1 NC_005125:c1943647-1943372 [Gloeobacter violaceus PCC 7421]
MTTPETRVMTAHVPILLADQVDLLAARLERSRGWIVKQALSAFVEQEEHRYRLTLEGLADVDAGRTIDHITVEAWAASLD
GDMPLPPPACR

Nucleotide

• Length: 276 bp

>AT20982 NC_005125:c1943647-1943372 [Gloeobacter violaceus PCC 7421]
ATGACTACGCCAGAAACCCGCGTCATGACTGCACACGTTCCGATTCTTTTAGCCGATCAGGTCGATCTGCTCGCAGCACG
TCTTGAGCGTTCGCGGGGCTGGATTGTAAAGCAAGCCCTGTCTGCGTTTGTTGAACAGGAAGAGCATCGCTACCGCCTGA
CCCTGGAAGGCTTAGCCGACGTTGATGCCGGGCGCACCATTGACCATATCACCGTTGAAGCATGGGCAGCCAGTCTTGAT
GGCGATATGCCTTTACCCCCGCCAGCATGCAGGTAA

Structures

Toxin

• AlphaFold DB: Q7NJK8

Antitoxin

• AlphaFold DB: Q7NJK7