Detailed information of TA system TA020981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 94907..95475
• Replicon: chromosome
• Accession: NC_005125
• Organism: Gloeobacter violaceus PCC 7421

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: Q7NPF9
• Locus tag: GLL_RS00490
• Protein ID: WP_011140100.1
• Coordinates: 95140..95475 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: Q7NPG0
• Locus tag: GLL_RS00485
• Protein ID: WP_011140099.1
• Coordinates: 94907..95146 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLL_RS00470	90488..90808	+	321	WP_011140096.1	hypothetical protein	-
GLL_RS00475	90832..92208	+	1377	WP_197530173.1	aminopeptidase P family protein	-
GLL_RS00480	92613..94766	+	2154	WP_164928426.1	caspase family protein	-
GLL_RS00485	94907..95146	+	240	WP_011140099.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GLL_RS00490	95140..95475	+	336	WP_011140100.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GLL_RS00495	95612..96085	-	474	WP_011140101.1	hypothetical protein	-
GLL_RS00500	96173..97906	+	1734	WP_011140102.1	ATP-binding cassette domain-containing protein	-
GLL_RS00505	97911..100118	-	2208	WP_164928427.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-109)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12634.76 Da
• Isoelectric Point: 7.8258

>T20981 WP_011140100.1 NC_005125:95140-95475 [Gloeobacter violaceus PCC 7421]
MVEYVPRRGEFIWLSFDPQAGHEQIGVRPALVVSQTLFNERLGFVFVCPVSNTQRKNPFYVLIPEGQAVTGVIMADQLRS
LDYRARRAAAISLCSEELLIEVLRKIQPILF

Nucleotide

• Length: 336 bp

>T20981 NC_005125:95140-95475 [Gloeobacter violaceus PCC 7421]
TTGGTAGAGTACGTTCCCCGGCGCGGCGAATTCATTTGGCTCAGTTTTGATCCACAAGCCGGGCATGAGCAGATAGGGGT
TCGCCCAGCCCTGGTGGTCAGCCAGACTCTGTTTAATGAAAGGCTTGGCTTTGTCTTCGTTTGTCCTGTCAGCAACACGC
AGCGCAAAAATCCGTTCTACGTACTTATCCCTGAAGGACAGGCAGTGACAGGGGTAATCATGGCCGATCAACTGCGCTCG
CTTGATTACCGAGCCCGGCGGGCAGCCGCGATCAGTTTATGCTCTGAGGAACTGCTGATAGAGGTGCTGCGCAAAATTCA
GCCGATTCTTTTTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8864.27 Da
• Isoelectric Point: 5.1067

>AT20981 WP_011140099.1 NC_005125:94907-95146 [Gloeobacter violaceus PCC 7421]
VKSQVARWGNSLAFRIPRQIVIQLGLKPHTTLLCSVEAGALVVRPVREVKEYSLEELLVGPLEVEDEVDWGKPEGKEAW

Nucleotide

• Length: 240 bp

>AT20981 NC_005125:94907-95146 [Gloeobacter violaceus PCC 7421]
GTGAAGTCGCAAGTGGCCCGCTGGGGGAATTCCCTCGCTTTTCGCATTCCCAGGCAGATTGTGATCCAACTTGGTCTCAA
GCCCCACACCACACTCCTATGCAGTGTAGAAGCCGGGGCTCTGGTTGTTCGGCCTGTGCGGGAGGTCAAAGAGTACAGCC
TTGAGGAGTTACTTGTCGGCCCGCTTGAAGTCGAAGACGAGGTCGATTGGGGCAAACCCGAAGGGAAAGAAGCTTGGTAG

Structures

Toxin

• AlphaFold DB: Q7NPF9

Antitoxin

• AlphaFold DB: Q7NPG0