Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4782271..4782787 Replicon chromosome
Accession NZ_CP079725
Organism Klebsiella pneumoniae strain KP3295

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KXI30_RS22970 Protein ID WP_004178374.1
Coordinates 4782271..4782555 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KXI30_RS22975 Protein ID WP_002886901.1
Coordinates 4782545..4782787 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXI30_RS22945 (4777755) 4777755..4778018 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
KXI30_RS22950 (4778148) 4778148..4778321 + 174 WP_032408826.1 hypothetical protein -
KXI30_RS22955 (4778324) 4778324..4779067 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KXI30_RS22960 (4779424) 4779424..4781562 + 2139 WP_219191791.1 anaerobic ribonucleoside-triphosphate reductase -
KXI30_RS22965 (4781803) 4781803..4782267 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KXI30_RS22970 (4782271) 4782271..4782555 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXI30_RS22975 (4782545) 4782545..4782787 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KXI30_RS22980 (4782865) 4782865..4784775 - 1911 WP_004178373.1 PRD domain-containing protein -
KXI30_RS22985 (4784798) 4784798..4785952 - 1155 WP_004178372.1 lactonase family protein -
KXI30_RS22990 (4786019) 4786019..4786759 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209802 WP_004178374.1 NZ_CP079725:c4782555-4782271 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209802 NZ_CP104312:747741-748226 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209802 WP_002886901.1 NZ_CP079725:c4782787-4782545 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209802 NZ_CP104312:747451-747744 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References