Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4052742..4053361 Replicon chromosome
Accession NZ_CP079725
Organism Klebsiella pneumoniae strain KP3295

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KXI30_RS19545 Protein ID WP_002892050.1
Coordinates 4053143..4053361 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KXI30_RS19540 Protein ID WP_002892066.1
Coordinates 4052742..4053116 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXI30_RS19530 (4047894) 4047894..4049087 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KXI30_RS19535 (4049110) 4049110..4052256 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KXI30_RS19540 (4052742) 4052742..4053116 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KXI30_RS19545 (4053143) 4053143..4053361 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KXI30_RS19550 (4053520) 4053520..4054086 + 567 WP_002892030.1 maltose O-acetyltransferase -
KXI30_RS19555 (4054058) 4054058..4054198 - 141 WP_004147370.1 hypothetical protein -
KXI30_RS19560 (4054219) 4054219..4054689 + 471 WP_002892026.1 YlaC family protein -
KXI30_RS19565 (4054664) 4054664..4056115 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KXI30_RS19570 (4056216) 4056216..4056914 + 699 WP_002892021.1 GNAT family protein -
KXI30_RS19575 (4056911) 4056911..4057051 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KXI30_RS19580 (4057051) 4057051..4057314 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209800 WP_002892050.1 NZ_CP079725:4053143-4053361 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209800 NZ_CP104312:331746-332114 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT209800 WP_002892066.1 NZ_CP079725:4052742-4053116 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209800 NZ_CP104312:331528-331749 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References