Detailed information of TA system TA209798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2737924..2739512
• Replicon: chromosome
• Accession: NZ_CP079725
• Organism: Klebsiella pneumoniae strain KP3295

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KXI30_RS13240
• Protein ID: WP_004179815.1
• Coordinates: 2737924..2739246 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KXI30_RS13245
• Protein ID: WP_004176198.1
• Coordinates: 2739246..2739512 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXI30_RS13225 (2732980)	2732980..2735481	+	2502	WP_020323802.1	fimbria/pilus outer membrane usher protein	-
KXI30_RS13230 (2735469)	2735469..2736473	+	1005	WP_004179822.1	fimbrial protein	-
KXI30_RS13235 (2736615)	2736615..2737907	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KXI30_RS13240 (2737924)	2737924..2739246	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KXI30_RS13245 (2739246)	2739246..2739512	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KXI30_RS13250 (2739778)	2739778..2740104	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
KXI30_RS13255 (2740101)	2740101..2740601	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KXI30_RS13260 (2740579)	2740579..2741958	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
KXI30_RS13265 (2742304)	2742304..2743458	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KXI30_RS13270 (2743439)	2743439..2744362	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T209798 WP_004179815.1 NZ_CP079725:c2739246-2737924 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209798 NZ_CP104310:30482-30757 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT209798 WP_004176198.1 NZ_CP079725:c2739512-2739246 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209798 NZ_CP104310:30198-30482 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA