Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 697198..697877 Replicon chromosome
Accession NZ_CP079725
Organism Klebsiella pneumoniae strain KP3295

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag KXI30_RS03410 Protein ID WP_020324801.1
Coordinates 697536..697877 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag KXI30_RS03405 Protein ID WP_020324792.1
Coordinates 697198..697515 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXI30_RS03380 (692412) 692412..695564 + 3153 WP_022631414.1 AIDA repeat-containing protein -
KXI30_RS03385 (695657) 695657..695896 + 240 WP_020324820.1 DUF905 domain-containing protein -
KXI30_RS03390 (695999) 695999..696457 + 459 WP_020324813.1 antirestriction protein -
KXI30_RS03395 (696473) 696473..696949 + 477 WP_020324797.1 RadC family protein -
KXI30_RS03400 (696958) 696958..697185 + 228 WP_020324796.1 DUF987 domain-containing protein -
KXI30_RS03405 (697198) 697198..697515 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KXI30_RS03410 (697536) 697536..697877 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
KXI30_RS03415 (697993) 697993..698826 + 834 WP_020324805.1 DUF4942 domain-containing protein -
KXI30_RS03425 (699129) 699129..699635 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
KXI30_RS03430 (699735) 699735..701576 - 1842 WP_219191792.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T209788 WP_020324801.1 NZ_CP079725:697536-697877 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T209788 NZ_CP104309:2897486-2897593 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT209788 WP_020324792.1 NZ_CP079725:697198-697515 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT209788 NZ_CP104309:c2897433-2897372 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References