Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4414320..4415861 Replicon chromosome
Accession NZ_CP079718
Organism Shewanella xiamenensis strain HD6416

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KXJ80_RS20475 Protein ID WP_218737475.1
Coordinates 4414320..4415621 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KXJ80_RS20480 Protein ID WP_105253052.1
Coordinates 4415625..4415861 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ80_RS20455 (KXJ80_20380) 4410277..4410570 + 294 WP_172591712.1 CU044_2847 family protein -
KXJ80_RS20460 (KXJ80_20385) 4410575..4411171 + 597 WP_218737473.1 serine protease -
KXJ80_RS20465 (KXJ80_20390) 4411546..4413243 + 1698 WP_218737474.1 hypothetical protein -
KXJ80_RS20470 (KXJ80_20395) 4413796..4414095 + 300 WP_109287664.1 type II toxin-antitoxin system HicB family antitoxin -
KXJ80_RS20475 (KXJ80_20400) 4414320..4415621 - 1302 WP_218737475.1 type II toxin-antitoxin system toxin serine/threonine-protein kinase HipA Toxin
KXJ80_RS20480 (KXJ80_20405) 4415625..4415861 - 237 WP_105253052.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KXJ80_RS20485 (KXJ80_20410) 4416299..4417936 - 1638 WP_037414230.1 chaperonin GroEL -
KXJ80_RS20490 (KXJ80_20415) 4417994..4418284 - 291 WP_011071021.1 co-chaperone GroES -
KXJ80_RS20495 (KXJ80_20420) 4418512..4419870 + 1359 WP_037414232.1 MATE family efflux transporter -
KXJ80_RS20500 (KXJ80_20425) 4419867..4420856 - 990 WP_218737476.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48731.95 Da        Isoelectric Point: 5.1897

>T209783 WP_218737475.1 NZ_CP079718:c4415621-4414320 [Shewanella xiamenensis]
MSTAKTLTLEMHLGDSIIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAIAFVPKGALLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GKEFAFAEGTLSSTHIVKFEKYHHLVINEFITMRLAKVIGMNVANVDIVHFGSYKALCVERFDRRYIPSEQRVLRRHIVD
SCQALGFSVSKKYERNFGTGRDVKDIREGVSFNRLFSLAEKCGNPVAAKQDMLQWTLFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVNVAMYEDFEQQLAMAIDDEFEPNSIYAYQLAAFMDGLGLPRNLLISNLTRMARRIPQAIAEVILMLPPLD
EDEASFVAHYKTQLLARCERYLGFVDEVRDVEV

Download         Length: 1302 bp

>T209783 NZ_CP104309:2141948-2142051 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8529.87 Da        Isoelectric Point: 6.2232

>AT209783 WP_105253052.1 NZ_CP079718:c4415861-4415625 [Shewanella xiamenensis]
MASPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSVQTSDTETNGWY

Download         Length: 237 bp

>AT209783 NZ_CP104309:c2142089-2141818 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References