209778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 5648785..5649424 Replicon chromosome
Accession NZ_CP079716
Organism Pseudomonas amygdali strain HS1

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z6Y3C5
Locus tag KXJ79_RS24795 Protein ID WP_005781617.1
Coordinates 5649242..5649424 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Z6UI77
Locus tag KXJ79_RS24790 Protein ID WP_058400065.1
Coordinates 5648785..5649210 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ79_RS24775 (KXJ79_24770) 5645250..5646572 + 1323 WP_058400091.1 murein hydrolase activator EnvC -
KXJ79_RS24780 (KXJ79_24775) 5646606..5647943 + 1338 WP_002551463.1 S41 family peptidase -
KXJ79_RS24785 (KXJ79_24780) 5647947..5648729 + 783 WP_058400066.1 divergent polysaccharide deacetylase family protein -
KXJ79_RS24790 (KXJ79_24785) 5648785..5649210 - 426 WP_058400065.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KXJ79_RS24795 (KXJ79_24790) 5649242..5649424 - 183 WP_005781617.1 type II toxin-antitoxin system HicA family toxin Toxin
KXJ79_RS24800 (KXJ79_24795) 5649746..5649985 + 240 Protein_4891 serine protease -
KXJ79_RS24805 (KXJ79_24800) 5649990..5650745 - 756 WP_058400090.1 ABC transporter substrate-binding protein -
KXJ79_RS24810 (KXJ79_24805) 5650930..5651700 - 771 WP_002551458.1 imidazole glycerol phosphate synthase subunit HisF -
KXJ79_RS24815 (KXJ79_24810) 5651720..5652457 - 738 WP_058407894.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
KXJ79_RS24820 (KXJ79_24815) 5652565..5652825 - 261 WP_002551456.1 DUF2164 domain-containing protein -
KXJ79_RS24825 (KXJ79_24820) 5652830..5653468 - 639 WP_005745046.1 imidazole glycerol phosphate synthase subunit HisH -
KXJ79_RS24830 (KXJ79_24825) 5653468..5654061 - 594 WP_002551454.1 imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6877.97 Da        Isoelectric Point: 10.6211

>T209778 WP_005781617.1 NZ_CP079716:c5649424-5649242 [Pseudomonas amygdali]
MKCNEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T209778 NZ_CP104309:c401368-400883 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15779.25 Da        Isoelectric Point: 5.2548

>AT209778 WP_058400065.1 NZ_CP079716:c5649210-5648785 [Pseudomonas amygdali]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEALSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERTA

Download         Length: 426 bp

>AT209778 NZ_CP104309:c401637-401359 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z6Y3C5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z6UI77

References