Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 5187789..5188384 Replicon chromosome
Accession NZ_CP079716
Organism Pseudomonas amygdali strain HS1

Toxin (Protein)


Gene name relE Uniprot ID A0A3M3ZKH5
Locus tag KXJ79_RS22555 Protein ID WP_005746690.1
Coordinates 5187789..5188091 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3M3ZMT7
Locus tag KXJ79_RS22560 Protein ID WP_054076832.1
Coordinates 5188094..5188384 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ79_RS22535 (KXJ79_22530) 5183123..5184400 - 1278 WP_058408659.1 precorrin-3B synthase -
KXJ79_RS22540 (KXJ79_22535) 5184589..5185790 + 1202 Protein_4449 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
KXJ79_RS22545 (KXJ79_22540) 5185790..5186902 + 1113 WP_058402638.1 cobalt-precorrin-5B (C(1))-methyltransferase -
KXJ79_RS22550 (KXJ79_22545) 5186899..5187639 + 741 WP_058402639.1 cobalt-precorrin-6A reductase -
KXJ79_RS22555 (KXJ79_22550) 5187789..5188091 + 303 WP_005746690.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXJ79_RS22560 (KXJ79_22555) 5188094..5188384 + 291 WP_054076832.1 putative addiction module antidote protein Antitoxin
KXJ79_RS22565 (KXJ79_22560) 5188455..5188916 + 462 WP_058402640.1 copper chaperone PCu(A)C -
KXJ79_RS22570 (KXJ79_22565) 5189005..5189364 + 360 WP_054076854.1 DUF2946 domain-containing protein -
KXJ79_RS22575 (KXJ79_22570) 5189449..5190822 + 1374 WP_219170302.1 PepSY domain-containing protein -
KXJ79_RS22580 (KXJ79_22575) 5191564..5192829 + 1266 WP_219170304.1 urea ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-86)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11477.21 Da        Isoelectric Point: 10.6008

>T209777 WP_005746690.1 NZ_CP079716:5187789-5188091 [Pseudomonas amygdali]
MNRFEQTPAFAEWLRSLKDSIGRARILARIRAAELGNFGDCDALGQGVRELRIHHGPGYRVYFARRTGVVYLLLIAGDKS
SQKRDIKFARQLARELCERE

Download         Length: 303 bp

>T209777 NZ_CP104309:352226-352753 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10514.89 Da        Isoelectric Point: 4.5720

>AT209777 WP_054076832.1 NZ_CP079716:5188094-5188384 [Pseudomonas amygdali]
MNNETTPFDTVDYLKTPEDMANYLDACLEEDSGDGLLIRAALNDIARAYGMTQIARDTGLGRESLYKALGANGNPEFTTI
MKVVRAMGIKLHASTR

Download         Length: 291 bp

>AT209777 NZ_CP104309:351953-352219 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3ZKH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3ZMT7

References