209775

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4396799..4397421 Replicon chromosome
Accession NZ_CP079716
Organism Pseudomonas amygdali strain HS1

Toxin (Protein)


Gene name hicA Uniprot ID A0A658PBH1
Locus tag KXJ79_RS19075 Protein ID WP_003434313.1
Coordinates 4397239..4397421 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A193SSY5
Locus tag KXJ79_RS19070 Protein ID WP_024661723.1
Coordinates 4396799..4397203 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXJ79_RS19055 (KXJ79_19055) 4392566..4393234 + 669 WP_219169879.1 ABC transporter ATP-binding protein -
KXJ79_RS19060 (KXJ79_19060) 4393234..4395713 + 2480 Protein_3758 ABC transporter permease -
KXJ79_RS19065 (KXJ79_19065) 4395703..4396782 + 1080 WP_219169880.1 lipocalin-like domain-containing protein -
KXJ79_RS19070 (KXJ79_19070) 4396799..4397203 - 405 WP_024661723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KXJ79_RS19075 (KXJ79_19075) 4397239..4397421 - 183 WP_003434313.1 type II toxin-antitoxin system HicA family toxin Toxin
KXJ79_RS19080 (KXJ79_19080) 4397705..4399477 + 1773 WP_044322414.1 N-acetylglutaminylglutamine amidotransferase -
KXJ79_RS19085 (KXJ79_19085) 4399481..4401229 + 1749 WP_219169881.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6777.99 Da        Isoelectric Point: 10.6643

>T209775 WP_003434313.1 NZ_CP079716:c4397421-4397239 [Pseudomonas amygdali]
VQSRQLIKELEADGWILDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

>T209775 NZ_CP104309:227372-227479 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14345.43 Da        Isoelectric Point: 5.1643

>AT209775 WP_024661723.1 NZ_CP079716:c4397203-4396799 [Pseudomonas amygdali]
MKYPMCIEWGSETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAAGGGTIPKAGTVAEHARNADFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIKQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT209775 NZ_CP104309:c227324-227258 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658PBH1

Antitoxin

Source ID Structure
AlphaFold DB A0A193SSY5

References