Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2704679..2705193 Replicon chromosome
Accession NZ_CP079715
Organism Staphylococcus aureus strain V8

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KX797_RS13660 Protein ID WP_000581792.1
Coordinates 2704679..2704888 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KX797_RS13665 Protein ID WP_000138932.1
Coordinates 2704900..2705193 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX797_RS13640 (2700187) 2700187..2701545 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KX797_RS13645 (2701560) 2701560..2702630 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KX797_RS13650 (2702948) 2702948..2704150 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KX797_RS13655 (2704414) 2704414..2704551 - 138 WP_000828354.1 Lmo0850 family protein -
KX797_RS13660 (2704679) 2704679..2704888 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KX797_RS13665 (2704900) 2704900..2705193 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KX797_RS13670 (2705359) 2705359..2706843 + 1485 WP_000571549.1 cardiolipin synthase -
KX797_RS13675 (2706871) 2706871..2707518 + 648 WP_176432636.1 HD domain-containing protein -
KX797_RS13680 (2708331) 2708331..2709203 - 873 WP_000725802.1 membrane protein insertase YidC -
KX797_RS13685 (2709289) 2709289..2709931 - 643 Protein_2663 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T209773 WP_000581792.1 NZ_CP079715:c2704888-2704679 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T209773 NZ_CP104303:c2768699-2768316 [Lacticaseibacillus paracasei]
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTTGAACGCAACTCAGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGCTTGGTTAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT209773 WP_000138932.1 NZ_CP079715:c2705193-2704900 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT209773 NZ_CP104303:c2768967-2768719 [Lacticaseibacillus paracasei]
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCGGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAACCAATTGATTT
CTGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGCATACGCCCAT
ATTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References