Detailed information of TA system TA209766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2471071..2471847
• Replicon: chromosome
• Accession: NZ_CP079715
• Organism: Staphylococcus aureus strain V8

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KX797_RS12235
• Protein ID: WP_000031108.1
• Coordinates: 2471071..2471223 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KX797_RS12240
• Protein ID: WP_001251224.1
• Coordinates: 2471248..2471847 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX797_RS12220 (2467034)	2467034..2467855	+	822	WP_176432633.1	RluA family pseudouridine synthase	-
KX797_RS12225 (2468318)	2468318..2469703	-	1386	WP_000116224.1	class II fumarate hydratase	-
KX797_RS12230 (2469899)	2469899..2470294	-	396	WP_000901021.1	hypothetical protein	-
KX797_RS12235 (2471071)	2471071..2471223	-	153	WP_000031108.1	SAS053 family protein	Toxin
KX797_RS12240 (2471248)	2471248..2471847	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KX797_RS12245 (2472006)	2472006..2472476	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KX797_RS12250 (2472481)	2472481..2473608	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
KX797_RS12255 (2473759)	2473759..2474481	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KX797_RS12260 (2474474)	2474474..2475931	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T209766 WP_000031108.1 NZ_CP079715:c2471223-2471071 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T209766 NZ_CP104302:2192759-2193166 [Mycolicibacterium brumae]
GTGATCGTCGACACCAGCGTATTGCTGGCTTTGTTCGACTCCAGGGATCCGCACCACGCGGCAGCCAGTGCCGCGATCGA
CAACACCGATGAGTTGCTGGTGGTGTCACCGTACGTCGTCGCCGAACTCGACTACCTCGTCGCCACCCGAATCGGTGTCG
AGGCCGAACTGGCCGTCCTTCGGGAATTGTCCGGCGGCGCATGGGAACTCGCCGAATTCACCCCGTCAGACCTACGCAAA
GCCGCCGAAGTCGTCGACAAATATCGCGACAAGCACATCGGCGTGGCGGACGCGTCAAACGTCGTACTCGCCGATCAGCA
TCAGACGCTCACCATTGCCACGCTAGACCGTCGCCATTTCGATGTTCTCCGACCGTTGAAAGGCGGACACTTCACGGTCG
TACCTTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT209766 WP_001251224.1 NZ_CP079715:c2471847-2471248 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT209766 NZ_CP104302:2192547-2192762 [Mycolicibacterium brumae]
GTGGATAAGACCACGATCTATCTGCCCGACGACCTGAAAGCCGCGGTCAAGCGCGCGGCACAGAAACGCGGCGTATCCGA
AGCCGAAGTTATCCGTGAATCGATTCGATCAACGGTCGGCAGCGAACGGCCGCGGCCACGAGGTGGCCTTTACGCAAGCG
ACGAAGCCCTCTCCGAGCGCGTCGACGAGCTGCTCGACGGCTTCGGCCAGCGGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4