Detailed information of TA system TA209766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2471071..2471847
• Replicon: chromosome
• Accession: NZ_CP079715
• Organism: Staphylococcus aureus strain V8

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KX797_RS12235
• Protein ID: WP_000031108.1
• Coordinates: 2471071..2471223 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KX797_RS12240
• Protein ID: WP_001251224.1
• Coordinates: 2471248..2471847 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T209766 WP_000031108.1 NZ_CP079715:c2471223-2471071 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T209766 NZ_CP104302:2192759-2193166 [Mycolicibacterium brumae]
GTGATCGTCGACACCAGCGTATTGCTGGCTTTGTTCGACTCCAGGGATCCGCACCACGCGGCAGCCAGTGCCGCGATCGA
CAACACCGATGAGTTGCTGGTGGTGTCACCGTACGTCGTCGCCGAACTCGACTACCTCGTCGCCACCCGAATCGGTGTCG
AGGCCGAACTGGCCGTCCTTCGGGAATTGTCCGGCGGCGCATGGGAACTCGCCGAATTCACCCCGTCAGACCTACGCAAA
GCCGCCGAAGTCGTCGACAAATATCGCGACAAGCACATCGGCGTGGCGGACGCGTCAAACGTCGTACTCGCCGATCAGCA
TCAGACGCTCACCATTGCCACGCTAGACCGTCGCCATTTCGATGTTCTCCGACCGTTGAAAGGCGGACACTTCACGGTCG
TACCTTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT209766 WP_001251224.1 NZ_CP079715:c2471847-2471248 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT209766 NZ_CP104302:2192547-2192762 [Mycolicibacterium brumae]
GTGGATAAGACCACGATCTATCTGCCCGACGACCTGAAAGCCGCGGTCAAGCGCGCGGCACAGAAACGCGGCGTATCCGA
AGCCGAAGTTATCCGTGAATCGATTCGATCAACGGTCGGCAGCGAACGGCCGCGGCCACGAGGTGGCCTTTACGCAAGCG
ACGAAGCCCTCTCCGAGCGCGTCGACGAGCTGCTCGACGGCTTCGGCCAGCGGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4