Detailed information of TA system TA209762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1378693..1379198
• Replicon: chromosome
• Accession: NZ_CP079715
• Organism: Staphylococcus aureus strain V8

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: KX797_RS06855
• Protein ID: WP_001103953.1
• Coordinates: 1378905..1379198 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: KX797_RS06850
• Protein ID: WP_001058486.1
• Coordinates: 1378693..1378902 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX797_RS06815 (1374210)	1374210..1375430	-	1221	WP_000264182.1	site-specific integrase	-
KX797_RS06820 (1375518)	1375518..1376246	-	729	WP_000733773.1	staphylococcal enterotoxin type K	-
KX797_RS06825 (1376270)	1376270..1376998	-	729	WP_001033317.1	staphylococcal enterotoxin type Q	-
KX797_RS06830 (1377173)	1377173..1377907	-	735	WP_000142630.1	helix-turn-helix transcriptional regulator	-
KX797_RS06835 (1378057)	1378057..1378269	+	213	WP_001063624.1	helix-turn-helix transcriptional regulator	-
KX797_RS06840 (1378270)	1378270..1378542	+	273	WP_001138298.1	helix-turn-helix domain-containing protein	-
KX797_RS06845 (1378554)	1378554..1378700	+	147	WP_000784893.1	hypothetical protein	-
KX797_RS06850 (1378693)	1378693..1378902	+	210	WP_001058486.1	hypothetical protein	Antitoxin
KX797_RS06855 (1378905)	1378905..1379198	+	294	WP_001103953.1	DUF1474 family protein	Toxin
KX797_RS06860 (1379286)	1379286..1380155	+	870	WP_001002692.1	primase alpha helix C-terminal domain-containing protein	-
KX797_RS06865 (1380172)	1380172..1381629	+	1458	WP_000432707.1	virulence-associated E family protein	-
KX797_RS06870 (1381931)	1381931..1382293	+	363	WP_001039172.1	hypothetical protein	-
KX797_RS06875 (1382295)	1382295..1382579	+	285	WP_000998180.1	hypothetical protein	-
KX797_RS06880 (1382576)	1382576..1383217	+	642	WP_001019780.1	hypothetical protein	-
KX797_RS06885 (1383661)	1383661..1384005	+	345	WP_001288441.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq	1356260..1438862	82602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-97)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11518.99 Da
• Isoelectric Point: 4.6582

>T209762 WP_001103953.1 NZ_CP079715:1378905-1379198 [Staphylococcus aureus]
MNWEIKDLMCDIEVVKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Nucleotide

• Length: 294 bp

>T209762 NZ_CP104302:c973348-972917 [Mycolicibacterium brumae]
GTGAAACGGGCGCTGCTCGATGTCAACGTCCTAATTGCGCTGTTCGACAGCGATCACGTCGACCACGGGCGAGTCCGCGC
ATGGCTGGCGGCCGAAATCGCACACGGCTGGGCTTCCTGCGCCATCACGCAGAACGGCTTCATCCGCATCATCAGCCAGC
CGCGATACCCGAGTCCGGTGGCGCCCGCCCAGGCGATAACGAGGCTCGCAACCGCCACCTCGACTGAGCATCATAAGTAC
TGGTCGTGTTCGATCAGCCTGCTGGACGCCGATCTCATTGACCACTCCAGGTTGCACGGCCATCGGCAAGTCACCGACGC
CTACCTGCTGGCGCTGGCCACCTCCAACGACGCCAGGTTCGTGACTCTCGACCAGTCGATCGGCCTGAATACCGTGCGGA
ATGCGACGCCGGACAACCTCACGGTGATCTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT209762 WP_001058486.1 NZ_CP079715:1378693-1378902 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT209762 NZ_CP104302:c973584-973345 [Mycolicibacterium brumae]
ATGCGCACCACACTCTCCCTGGACGACGACGTGCTGCTCGCGGTGAAGGAGCGGGCACGCCGGGAGAAGCGCACCGCCGG
CGAGGTGCTCTCCGACCTGGCTCGACACGCTCTGCAGCAGCACAGCGCCGAATCCGGGCGAGCGACGGGCGACCTCCACG
GCTTCGAACCGTTCGGGCGCCGCGGACCCGCGGTCTCGAACGCGTTGGTCGACAAACTGCGTGACGAGGAAGCCGTGTGA