Detailed information of TA system TA209761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1361576..1362053
• Replicon: chromosome
• Accession: NZ_CP079715
• Organism: Staphylococcus aureus strain V8

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: KX797_RS06720
• Protein ID: WP_000052078.1
• Coordinates: 1361576..1361764 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KX797_RS06725
• Protein ID: WP_001059690.1
• Coordinates: 1361793..1362053 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX797_RS06690 (1357617)	1357617..1358087	+	471	WP_000824472.1	hypothetical protein	-
KX797_RS06695 (1358428)	1358428..1359114	+	687	WP_001548082.1	thermonuclease family protein	-
KX797_RS06700 (1359471)	1359471..1359671	+	201	WP_001059082.1	cold-shock protein	-
KX797_RS06705 (1360167)	1360167..1360385	-	219	WP_000005886.1	hypothetical protein	-
KX797_RS06710 (1360447)	1360447..1360731	-	285	WP_001004395.1	hypothetical protein	-
KX797_RS06715 (1360819)	1360819..1361388	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
KX797_RS06720 (1361576)	1361576..1361764	-	189	WP_000052078.1	hypothetical protein	Toxin
KX797_RS06725 (1361793)	1361793..1362053	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KX797_RS06730 (1362394)	1362394..1362597	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KX797_RS06735 (1362594)	1362594..1362830	-	237	WP_000368687.1	hypothetical protein	-
KX797_RS06740 (1363055)	1363055..1363636	+	582	WP_219098911.1	histidine phosphatase family protein	-
KX797_RS06745 (1363709)	1363709..1364326	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
KX797_RS06750 (1364481)	1364481..1364975	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KX797_RS06755 (1365374)	1365374..1365796	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
KX797_RS06760 (1365944)	1365944..1366660	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq	1356260..1438862	82602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T209761 WP_000052078.1 NZ_CP079715:c1361764-1361576 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T209761 NZ_CP104302:c838156-837827 [Mycolicibacterium brumae]
ATGAGCGGATTGCCAACACGTGGCGAAGTGTGGTGGTGCGAACTGCCAGACATCGGTCGACGTCCCGTCGTCGTGATCTC
CCGCGACGTGGCGATTCCCCGTACACGCCGGCCCCTGGTCGCACCTTGCACCACCACGATCAGGGGCCTACCAAGCGAAG
TTCAGCTGGAACCGGGCGTCGACCCGGTTCCTCGGCCATCGGCAGTCAACCTCGATTCCATCGAGAGCGTCGCCATCGGC
TCACTGGTCGAGCGACTCGGGAGACTTGCCGACGATCGAATGCGCGCGATCTGCAGCGCCCTGAAAGTCGCGACGGGCTG
CGGCGCCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT209761 WP_001059690.1 NZ_CP079715:c1362053-1361793 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT209761 NZ_CP104302:c838389-838153 [Mycolicibacterium brumae]
ATGTCTCGCATACGCGTTTCGACGACGGTGGACGCCGACCTTCTCCACGCCGCCCGCCAAACCCGATCCGGCGGCACCGA
CGCGTCGTTGCTGGACGCGGCACTCAGTGCCCTGCTCACCGCACATCGCGCAGCGCAGATCGACGCCGCCTACGTCGCCT
ATGACTCCCAGCCGCTGTCGGATCCTGATGAGTGGGGCGACCTGGCCTCGTGGCGTGACGCCGCAGGGTCATCATGA

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40

Antitoxin

• AlphaFold DB: A0A0E0VN56