Detailed information of TA system TA209756

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3964224..3964884
• Replicon: chromosome
• Accession: NZ_CP079713
• Organism: Salmonella enterica subsp. arizonae strain LHICA_AZ23

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KX325_RS18950
• Protein ID: WP_079782365.1
• Coordinates: 3964471..3964884 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A741MZI1
• Locus tag: KX325_RS18945
• Protein ID: WP_000354051.1
• Coordinates: 3964224..3964490 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX325_RS18925 (3960168)	3960168..3961601	-	1434	WP_079835405.1	6-phospho-beta-glucosidase	-
KX325_RS18930 (3961759)	3961759..3962070	+	312	WP_001182982.1	N(4)-acetylcytidine aminohydrolase	-
KX325_RS18935 (3962233)	3962233..3962892	+	660	WP_000250284.1	hemolysin III family protein	-
KX325_RS18940 (3962994)	3962994..3963974	-	981	WP_079835404.1	tRNA-modifying protein YgfZ	-
KX325_RS18945 (3964224)	3964224..3964490	+	267	WP_000354051.1	FAD assembly factor SdhE	Antitoxin
KX325_RS18950 (3964471)	3964471..3964884	+	414	WP_079782365.1	protein YgfX	Toxin
KX325_RS18955 (3964937)	3964937..3965458	-	522	WP_079782364.1	flavodoxin FldB	-
KX325_RS18960 (3965571)	3965571..3966467	+	897	WP_000434304.1	site-specific tyrosine recombinase XerD	-
KX325_RS18965 (3966491)	3966491..3967204	+	714	WP_079782363.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KX325_RS18970 (3967210)	3967210..3968943	+	1734	WP_079782362.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16341.38 Da
• Isoelectric Point: 10.4028

>T209756 WP_079782365.1 NZ_CP079713:3964471-3964884 [Salmonella enterica subsp. arizonae]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAEPGRYQHLWLAADSMEDAEWRELRRIMLQQPISREH

Nucleotide

• Length: 414 bp

>T209756 NZ_CP104301:c5243687-5243409 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10496.00 Da
• Isoelectric Point: 6.2227

>AT209756 WP_000354051.1 NZ_CP079713:3964224-3964490 [Salmonella enterica subsp. arizonae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDGEKRIFIRLLQNDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209756 NZ_CP104301:c5243397-5243092 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Antitoxin

• AlphaFold DB: A0A741MZI1