Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3889497..3890087 Replicon chromosome
Accession NZ_CP079713
Organism Salmonella enterica subsp. arizonae strain LHICA_AZ23

Toxin (Protein)


Gene name pemK Uniprot ID A0A741MVU5
Locus tag KX325_RS18575 Protein ID WP_000373725.1
Coordinates 3889755..3890087 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A741N4R3
Locus tag KX325_RS18570 Protein ID WP_000288813.1
Coordinates 3889497..3889754 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX325_RS18540 (3884977) 3884977..3886200 + 1224 WP_079835284.1 RHS repeat-associated core domain-containing protein -
KX325_RS18545 (3886405) 3886405..3886659 + 255 Protein_3636 transposase -
KX325_RS18550 (3886890) 3886890..3887504 + 615 Protein_3637 transposase -
KX325_RS18555 (3887518) 3887518..3888435 + 918 Protein_3638 IS3 family transposase -
KX325_RS18560 (3888486) 3888486..3888947 + 462 WP_079829722.1 hypothetical protein -
KX325_RS18565 (3888944) 3888944..3889149 + 206 Protein_3640 helix-turn-helix domain-containing protein -
KX325_RS18570 (3889497) 3889497..3889754 + 258 WP_000288813.1 hypothetical protein Antitoxin
KX325_RS18575 (3889755) 3889755..3890087 + 333 WP_000373725.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KX325_RS18580 (3890936) 3890936..3891607 + 672 Protein_3643 integrase domain-containing protein -
KX325_RS18585 (3892135) 3892135..3893396 - 1262 Protein_3644 integrase arm-type DNA-binding domain-containing protein -
KX325_RS18595 (3893739) 3893739..3894446 - 708 WP_000234459.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3875259..3891079 15820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11779.61 Da        Isoelectric Point: 10.7239

>T209755 WP_000373725.1 NZ_CP079713:3889755-3890087 [Salmonella enterica subsp. arizonae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFAVSLDGAGTRTTGVIRCDQPRTI
DMGARNGKRLERLPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T209755 NZ_CP104301:c3926023-3925154 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9332.80 Da        Isoelectric Point: 4.3093

>AT209755 WP_000288813.1 NZ_CP079713:3889497-3889754 [Salmonella enterica subsp. arizonae]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPRKRPCYSLEELLAQCDPNAEISEEDREWIDAPAV
GREIL

Download         Length: 258 bp

>AT209755 NZ_CP104301:c3925161-3924328 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A741MVU5

Antitoxin

Source ID Structure
AlphaFold DB A0A741N4R3

References