Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2636673..2637189 | Replicon | chromosome |
| Accession | NZ_CP079713 | ||
| Organism | Salmonella enterica subsp. arizonae strain LHICA_AZ23 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V1HEI0 |
| Locus tag | KX325_RS12790 | Protein ID | WP_000220584.1 |
| Coordinates | 2636905..2637189 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A741SJM0 |
| Locus tag | KX325_RS12785 | Protein ID | WP_000212720.1 |
| Coordinates | 2636673..2636915 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KX325_RS12750 (2632813) | 2632813..2633364 | - | 552 | WP_000166292.1 | ribosome biogenesis factor YjgA | - |
| KX325_RS12755 (2633460) | 2633460..2634812 | + | 1353 | WP_079835264.1 | metalloprotease PmbA | - |
| KX325_RS12760 (2634861) | 2634861..2635247 | + | 387 | WP_001225535.1 | cytochrome b562 | - |
| KX325_RS12765 (2635525) | 2635525..2635863 | + | 339 | WP_077905506.1 | glycine dehydrogenase | - |
| KX325_RS12775 (2635961) | 2635961..2636263 | + | 303 | WP_024132044.1 | DUF4312 family protein | - |
| KX325_RS12780 (2636346) | 2636346..2636594 | + | 249 | Protein_2518 | transcription antiterminator BglG | - |
| KX325_RS12785 (2636673) | 2636673..2636915 | + | 243 | WP_000212720.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| KX325_RS12790 (2636905) | 2636905..2637189 | + | 285 | WP_000220584.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KX325_RS12795 (2637199) | 2637199..2637663 | - | 465 | WP_058819816.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
| KX325_RS12800 (2637819) | 2637819..2639957 | - | 2139 | WP_000187814.1 | anaerobic ribonucleoside-triphosphate reductase | - |
| KX325_RS12805 (2640366) | 2640366..2641977 | - | 1612 | Protein_2523 | alpha,alpha-phosphotrehalase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11085.02 Da Isoelectric Point: 10.3015
>T209753 WP_000220584.1 NZ_CP079713:2636905-2637189 [Salmonella enterica subsp. arizonae]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL
Download Length: 285 bp
>T209753 NZ_CP104301:c2048580-2048002 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
TCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
TCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9043.41 Da Isoelectric Point: 5.0651
>AT209753 WP_000212720.1 NZ_CP079713:2636673-2636915 [Salmonella enterica subsp. arizonae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDTLLQTVRERLANPQKGIRVSLDDL
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDTLLQTVRERLANPQKGIRVSLDDL
Download Length: 243 bp
>AT209753 NZ_CP104301:c2049223-2048669 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A741MVA9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A741SJM0 |