Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1988866..1989486 Replicon chromosome
Accession NZ_CP079713
Organism Salmonella enterica subsp. arizonae strain LHICA_AZ23

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KX325_RS09720 Protein ID WP_001280991.1
Coordinates 1989268..1989486 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A741MU25
Locus tag KX325_RS09715 Protein ID WP_000344793.1
Coordinates 1988866..1989240 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX325_RS09705 (1984002) 1984002..1985195 + 1194 WP_001039197.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KX325_RS09710 (1985218) 1985218..1988367 + 3150 WP_001132516.1 efflux RND transporter permease AcrB -
KX325_RS09715 (1988866) 1988866..1989240 + 375 WP_000344793.1 Hha toxicity modulator TomB Antitoxin
KX325_RS09720 (1989268) 1989268..1989486 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KX325_RS09725 (1989665) 1989665..1990216 + 552 WP_001278797.1 maltose O-acetyltransferase -
KX325_RS09730 (1990334) 1990334..1990804 + 471 WP_000136186.1 YlaC family protein -
KX325_RS09735 (1990859) 1990859..1990999 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KX325_RS09740 (1991005) 1991005..1991265 - 261 WP_000801420.1 type B 50S ribosomal protein L31 -
KX325_RS09745 (1991490) 1991490..1993040 + 1551 WP_079835185.1 EAL domain-containing protein -
KX325_RS09755 (1993271) 1993271..1993660 + 390 WP_079781156.1 MGMT family protein -
KX325_RS09760 (1993693) 1993693..1994262 - 570 WP_079781157.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T209752 WP_001280991.1 NZ_CP079713:1989268-1989486 [Salmonella enterica subsp. arizonae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T209752 NZ_CP104301:800476-800823 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14380.17 Da        Isoelectric Point: 4.8673

>AT209752 WP_000344793.1 NZ_CP079713:1988866-1989240 [Salmonella enterica subsp. arizonae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGLVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRQSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT209752 NZ_CP104301:800215-800466 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A741MU25

References