Detailed information of TA system TA209751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 999216..999817
• Replicon: chromosome
• Accession: NZ_CP079713
• Organism: Salmonella enterica subsp. arizonae strain LHICA_AZ23

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: KX325_RS04850
• Protein ID: WP_079781811.1
• Coordinates: 999216..999599 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A741MYH8
• Locus tag: KX325_RS04855
• Protein ID: WP_001195491.1
• Coordinates: 999596..999817 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KX325_RS04835 (995377)	995377..996579	-	1203	WP_079781808.1	MalY/PatB family protein	-
KX325_RS04840 (996592)	996592..998043	-	1452	WP_079829535.1	Na+/H+ antiporter NhaC	-
KX325_RS04845 (998187)	998187..999194	-	1008	WP_079781810.1	LacI family DNA-binding transcriptional regulator	-
KX325_RS04850 (999216)	999216..999599	-	384	WP_079781811.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KX325_RS04855 (999596)	999596..999817	-	222	WP_001195491.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KX325_RS04860 (1000601)	1000601..1001362	-	762	WP_079829534.1	Tox-REase-5 domain-containing protein	-
KX325_RS04865 (1001578)	1001578..1002060	-	483	WP_140197924.1	hypothetical protein	-
KX325_RS04870 (1002418)	1002418..1003217	-	800	Protein_958	IS3 family transposase	-
KX325_RS04875 (1003298)	1003298..1003420	-	123	Protein_959	transposase	-
KX325_RS04880 (1003673)	1003673..1004398	-	726	WP_001122177.1	type III secretion system effector phosphothreonine lyase SpvC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14525.55 Da
• Isoelectric Point: 6.9892

>T209751 WP_079781811.1 NZ_CP079713:c999599-999216 [Salmonella enterica subsp. arizonae]
MIWVSAQEVIAFHDRILQRFPGVVGLSDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MVFLRRNGIRIHDTDNTLENLTVEAATGEKTVDQLAQYLRKQVDDPL

Nucleotide

• Length: 384 bp

>T209751 NZ_CP104301:c143848-143567 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8176.10 Da
• Isoelectric Point: 5.0053

>AT209751 WP_001195491.1 NZ_CP079713:c999817-999596 [Salmonella enterica subsp. arizonae]
MQTYTSTQARANISTVLDTALNGEPVEITRRDGSAAVLISKAEFEAWQNAKLDAEFDAIMQRHEHTIRALTDR

Nucleotide

• Length: 222 bp

>AT209751 NZ_CP104301:c144072-143845 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A741MYH8