Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 342240..342708 Replicon chromosome
Accession NZ_CP079713
Organism Salmonella enterica subsp. arizonae strain LHICA_AZ23

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KX325_RS01560 Protein ID WP_249272868.1
Coordinates 342472..342708 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KX325_RS01555 Protein ID WP_012209976.1
Coordinates 342240..342413 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KX325_RS01535 (337970) 337970..339490 + 1521 WP_000255142.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
KX325_RS01540 (339506) 339506..340516 + 1011 WP_000114953.1 galactose/methyl galactoside ABC transporter permease MglC -
KX325_RS01545 (340565) 340565..340855 - 291 Protein_299 NAD-dependent dihydropyrimidine dehydrogenase subunit PreA -
KX325_RS01555 (342240) 342240..342413 + 174 WP_012209976.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
KX325_RS01560 (342472) 342472..342708 + 237 WP_249272868.1 CcdB family protein Toxin
KX325_RS01565 (342790) 342790..342948 + 159 Protein_303 ISNCY family transposase -
KX325_RS01570 (342948) 342948..343747 - 800 Protein_304 DUF1460 domain-containing protein -
KX325_RS01575 (343955) 343955..344119 + 165 WP_164504055.1 hypothetical protein -
KX325_RS01580 (344042) 344042..344418 - 377 Protein_306 dihydropyrimidine dehydrogenase -
KX325_RS01585 (344623) 344623..344868 - 246 WP_079829113.1 DUF2542 family protein -
KX325_RS01590 (344865) 344865..345584 - 720 WP_000920069.1 outer membrane permeability protein SanA -
KX325_RS01595 (345813) 345813..346283 + 471 Protein_309 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 340873..346343 5470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(1-45)

Antitoxin

Post-segregation antitoxin CcdA

(2-57)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8891.36 Da        Isoelectric Point: 7.2768

>T209742 WP_249272868.1 NZ_CP079713:342472-342708 [Salmonella enterica subsp. arizonae]
IIDTPGRRMVIPLARALLLSDKVSRELYPVVHIGEESYRLMTTDILMSLNPFSDVTFSGMKDPILRPWGHQDACNHVR

Download         Length: 237 bp

>T209742 NZ_CP104292:265897-266202 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGGATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6685.49 Da        Isoelectric Point: 5.7658

>AT209742 WP_012209976.1 NZ_CP079713:342240-342413 [Salmonella enterica subsp. arizonae]
MLKAYDVNISRLVSTTMQHEARRLRAKRWQAENQEGMAEVALFIETNGSFADENRDW

Download         Length: 174 bp

>AT209742 NZ_CP104292:266243-266545 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References