209740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4717628..4718236 Replicon chromosome
Accession NZ_CP079712
Organism Pseudomonas aeruginosa strain PAO1-UW

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag KXE08_RS21870 Protein ID WP_003114156.1
Coordinates 4717628..4717975 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag KXE08_RS21875 Protein ID WP_003114155.1
Coordinates 4717985..4718236 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXE08_RS21840 (KXE08_21770) 4712987..4713259 + 273 WP_010895521.1 cysteine-rich CWC family protein -
KXE08_RS21845 (KXE08_21775) 4713259..4713951 + 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
KXE08_RS21850 (KXE08_21780) 4714087..4715130 + 1044 WP_003098363.1 L,D-transpeptidase -
KXE08_RS21855 (KXE08_21785) 4715210..4715947 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
KXE08_RS21860 (KXE08_21790) 4716399..4717301 + 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
KXE08_RS21870 (KXE08_21800) 4717628..4717975 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXE08_RS21875 (KXE08_21805) 4717985..4718236 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KXE08_RS21880 (KXE08_21810) 4718450..4719433 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
KXE08_RS21885 (KXE08_21815) 4719433..4720725 - 1293 WP_003115206.1 hypothetical protein -
KXE08_RS21890 (KXE08_21820) 4720955..4722229 - 1275 WP_010895520.1 zonular occludens toxin family protein -
KXE08_RS21895 (KXE08_21825) 4722233..4722589 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4708524..4739805 31281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T209740 WP_003114156.1 NZ_CP079712:c4717975-4717628 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T209740 NZ_CP104290:c733639-732770 [Stenotrophomonas maltophilia]
GTGACCCACTCTCCACCACTCCCCCAGCGCGTTGCTTCCATCCGGCAACGGCTGCTCGATCTCGCTCGCAGCCGAGGCGA
GGACTTTCAGTTCGTGCTGGACCGGTTCGCCGTTGAGCGCCTGCTCTACCGACTCTCCGCTTCCCGATACCGCGACCAGT
TCCTGCTGAAGGGCGCCATGTTGTTTGCAGTGTGGTTCGACGCGCCCCACCGTCCCACGCGGGATGCCGATTTTCTGCGA
TTCGGCTCTGCAGATCCCGACCATCTGCTGCACATCGCACGGTCGCTCTGTGCAATACCGGACGACGACGGCCTATGCTT
CGACCCGGGCAGCATCGCCATCGAGGCCACCCGCGAAGAAGCGGAGTATGAGGGGTTGCGAATCCGCCTGACCGCACATC
TTGGCCGCTCGCGCTGCCACGTACAGTGGGACGTGGGGTTTGGCGATGCGGTGACTCCCCCACCGCCGGAAATCGCCTAC
CCGGTGATGCTGGATGGCTTTCCTCTCCCCTGCCTGCACGTCTATCCGCGCGAGACCGTGTTTGCCGAAAAGCTGGAGGC
CATTGCGGCACTGGGCATCGCAAACAGCAGGATGAAGGACTTCTTCGACTTGCTGGCACTGGTCCGCGAAGACGCCATGG
ATCGTCCACACCTTGTTGCGGCCATTGGCGCGACGTTTGATCGGCGAGGGACCCCGGCGCCGCCCCCCTTGCCCTACGGA
CTGACACAGTCGTTCGCCGCAGATACCCAGAAGCAGACCCAGTGGCGCGCCTTCCTGCGCAGGAATCGCCTGATCGCGCC
GGATCTCTCTTCGGTGATTGCCGAGATTGCCGACTATCTGGACACCCTCGACACAACCGTACAGTCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT209740 WP_003114155.1 NZ_CP079712:c4718236-4717985 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT209740 NZ_CP104290:c734238-733636 [Stenotrophomonas maltophilia]
ATGGGAAACGCCGAGGCCAACGCACGAAAGCTGTTGCGACGCGCAGGCACCCTGCGCGCCCGCGAGCTGGTGACCGCCGG
GATCGCCCGCGCCCAGCTGACCCGACTGGTCGAGGCCGGTGCGCTGATCCGGCTGTCTCGTGGCGTCTACGCGTTGGCGG
AAAGAAACAGTGACGACACCGATGATGGACTGCGGATCATTGCCGAACGCCTGCCGCACCCCCGTCTGTGCCTGTTGAGT
GCCCTGCGCCTGCATGGCCTGACCACCCAGGCGCCATTCGAACGCTGGGTCTCCATCGGCAACAGCGACCGCGTTCCGCG
GATCGATTGGCCGCCCCTCCGAGTGGTCCGCATGTCGGCAAAGACCCTCAACGCGGGGCTGGAAGAGCGTCGCGTAGGCA
AACATCTCATATACGTCAGCAATGTAGCCAAAACCGTCGTCGATTGCTTCAAGTTCCGCAATCTCGTAGGACTTGATGTC
GCAATTGAAGCCCTGCGTGACGCGCTTCACAGCCGTGCGACCACGCCGGATGCGCTGATGGAGTATGCGCGGATCTGCCG
CGTTGCCAGACTGATGAGACCGTACCTCGATGCCCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References