Detailed information of TA system TA209739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4397833..4399091
• Replicon: chromosome
• Accession: NZ_CP079712
• Organism: Pseudomonas aeruginosa strain PAO1-UW

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: KXE08_RS20285
• Protein ID: WP_003112528.1
• Coordinates: 4397833..4398588 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KXE08_RS20290
• Protein ID: WP_003086329.1
• Coordinates: 4398723..4399091 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXE08_RS20275 (KXE08_20215)	4393006..4395549	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
KXE08_RS20280 (KXE08_20220)	4395704..4397065	-	1362	WP_010895536.1	DNA recombination protein RmuC	-
KXE08_RS20285 (KXE08_20225)	4397833..4398588	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
KXE08_RS20290 (KXE08_20230)	4398723..4399091	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KXE08_RS20295 (KXE08_20235)	4399164..4400450	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
KXE08_RS20300 (KXE08_20240)	4400506..4402095	-	1590	WP_010895535.1	aldehyde dehydrogenase family protein	-
KXE08_RS20305 (KXE08_20245)	4402174..4402650	+	477	WP_003112531.1	hypothetical protein	-
KXE08_RS20310 (KXE08_20250)	4402653..4402928	-	276	WP_010793902.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T209739 WP_003112528.1 NZ_CP079712:c4398588-4397833 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T209739 NZ_CP104290:318727-319029 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT209739 WP_003086329.1 NZ_CP079712:c4399091-4398723 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT209739 NZ_CP104290:318381-318686 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7