Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3465429..3466650 Replicon chromosome
Accession NZ_CP079712
Organism Pseudomonas aeruginosa strain PAO1-UW

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KXE08_RS15905 Protein ID WP_003114949.1
Coordinates 3466072..3466650 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KXE08_RS15900 Protein ID WP_003088112.1
Coordinates 3465429..3465983 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXE08_RS15875 (KXE08_15830) 3460997..3461548 + 552 WP_003102727.1 XRE family transcriptional regulator -
KXE08_RS15880 (KXE08_15835) 3461545..3461943 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KXE08_RS15885 (KXE08_15840) 3461956..3462279 - 324 WP_003102734.1 multidrug efflux SMR transporter -
KXE08_RS15890 (KXE08_15845) 3462610..3463071 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KXE08_RS15895 (KXE08_15850) 3463076..3465271 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KXE08_RS15900 (KXE08_15855) 3465429..3465983 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KXE08_RS15905 (KXE08_15860) 3466072..3466650 + 579 WP_003114949.1 HD domain-containing protein Toxin
KXE08_RS15910 (KXE08_15865) 3466758..3467945 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KXE08_RS15915 (KXE08_15870) 3467935..3470106 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
KXE08_RS15920 (KXE08_15875) 3470096..3471373 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T209738 WP_003114949.1 NZ_CP079712:3466072-3466650 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T209738 NZ_CP104290:318381-318686 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT209738 WP_003088112.1 NZ_CP079712:3465429-3465983 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT209738 NZ_CP104290:318727-319029 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References