209736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1588972..1590667 Replicon chromosome
Accession NZ_CP079712
Organism Pseudomonas aeruginosa strain PAO1-UW

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag KXE08_RS07410 Protein ID WP_003112901.1
Coordinates 1588972..1589841 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag KXE08_RS07415 Protein ID WP_003112902.1
Coordinates 1589834..1590667 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXE08_RS07385 (KXE08_07370) 1584980..1585831 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
KXE08_RS07390 (KXE08_07375) 1585872..1586879 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
KXE08_RS07395 (KXE08_07380) 1586876..1587652 + 777 WP_003112898.1 ABC transporter permease -
KXE08_RS07400 (KXE08_07385) 1587658..1588419 + 762 WP_003112899.1 SDR family oxidoreductase -
KXE08_RS07405 (KXE08_07390) 1588433..1588963 + 531 WP_003112900.1 cupin domain-containing protein -
KXE08_RS07410 (KXE08_07395) 1588972..1589841 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
KXE08_RS07415 (KXE08_07400) 1589834..1590667 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
KXE08_RS07420 (KXE08_07405) 1590654..1591451 + 798 WP_003112903.1 SDR family oxidoreductase -
KXE08_RS07425 (KXE08_07410) 1591444..1593126 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
KXE08_RS07430 (KXE08_07415) 1593137..1593940 + 804 WP_003112905.1 aspartate dehydrogenase -
KXE08_RS07435 (KXE08_07420) 1593952..1595436 + 1485 WP_003112906.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T209736 WP_003112901.1 NZ_CP079712:1588972-1589841 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

>T209736 NZ_CP104288:c2827255-2827079 [Stenotrophomonas maltophilia]
ATGAAGAGCAGGGACCTCATCCGGGATCTGGAAGCGGCATGTTGGATCTGTCGTCGGATCCGCGGATCCCATCATGTATT
CGTGCACCCGCAGCACCCTCACATCATCACCGTTCCTCAGCCAAGGAAGGATCTGGGGAAGGGCTGGTACAGGCGTTGCG
GAAGCTCGCAGGACTGA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT209736 WP_003112902.1 NZ_CP079712:1589834-1590667 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp

>AT209736 NZ_CP104288:c2827065-2826964 [Stenotrophomonas maltophilia]
ATGCGATATCCAGTCTTGATCGAGGCAGGCGATGAGCGCACCGCGTGGGGTGTGGTCGTTCCAGATCTGCCGGGGGTGCT
TCTCGGCGGCCGACACGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References